p53 Activators
Items 11 to 20 of 26 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NSC 319726 | 71555-25-4 | sc-477736 | 10 mg | $159.00 | ||
NSC319726 induces p53-mediated apoptosis by disrupting the p53-MDM2 interaction. | ||||||
JNJ 26854165 | 881202-45-5 | sc-364514 sc-364514A | 5 mg 25 mg | $171.00 $577.00 | ||
JNJ 26854165 exhibits remarkable properties as a p53 modulator, engaging in selective interactions that promote the stabilization of the p53 protein. Its unique structural features allow for enhanced binding affinity, which influences the protein's regulatory functions in the cell cycle. The compound's dynamic behavior in various environments showcases its ability to alter molecular interactions, impacting downstream signaling pathways and cellular responses to stress. | ||||||
HR-73 | 959571-93-8 | sc-255207 | 5 mg | $156.00 | ||
HR-73 functions as a potent p53 modulator, characterized by its ability to selectively disrupt the interaction between p53 and its negative regulators. This compound enhances the transcriptional activity of p53, facilitating the activation of target genes involved in apoptosis and cell cycle arrest. Its unique conformation allows for specific binding to regulatory sites, influencing the kinetics of p53-mediated pathways and promoting cellular resilience under stress conditions. | ||||||
PhiKan-083 Hydrochloride | 880813-36-5 | sc-479264 | 10 mg | $320.00 | ||
PhiKan083 activates the tumor suppressor protein p53 by disrupting its interaction with the protein MDM2, which normally inhibits p53. It achieves this by binding to p53 at a specific site, altering its shape and preventing MDM2 from binding to and degrading p53. This leads to the stabilization and accumulation of p53 in cells, thereby enabling it to perform its tumor-suppressing functions more effectively. | ||||||
CHS-828 | 200484-11-3 | sc-364106 sc-364106A | 5 mg 25 mg | $84.00 $338.00 | ||
CHS-828 acts as a distinctive p53 regulator, exhibiting a unique mechanism that stabilizes the p53 protein by preventing its degradation. This compound engages in specific molecular interactions that enhance p53's structural integrity, thereby promoting its functional longevity. By modulating the protein's conformational dynamics, CHS-828 influences downstream signaling pathways, leading to an increased transcriptional response to cellular stressors and altered gene expression profiles. | ||||||
NSC 66811 | 6964-62-1 | sc-311507 sc-311507A | 10 mg 50 mg | $162.00 $683.00 | ||
NSC 66811 functions as a notable p53 modulator, characterized by its ability to enhance p53 activity through unique binding interactions that stabilize the protein's conformation. This compound influences the post-translational modifications of p53, facilitating its accumulation in the nucleus. By altering the kinetics of p53's interaction with regulatory proteins, NSC 66811 effectively shifts cellular responses to stress, impacting gene regulation and apoptotic pathways. | ||||||
Etoposide-d3 | sc-218445 | 1 mg | $449.00 | 9 | ||
Etoposide-d3 acts as a potent p53 activator, distinguished by its capacity to induce DNA damage response pathways. This compound interacts with topoisomerase II, leading to the stabilization of DNA double-strand breaks. Its unique isotopic labeling allows for precise tracking in cellular studies, enhancing the understanding of p53-mediated transcriptional regulation. Etoposide-d3 also modulates the cellular microenvironment, influencing oxidative stress responses and apoptosis. | ||||||
PRIMA-1 | 5608-24-2 | sc-200927 sc-200927A | 5 mg 25 mg | $102.00 $408.00 | 1 | |
PRIMA-1 is a small molecule that reactivates mutant p53 by restoring its wild-type conformation, facilitating its ability to bind to DNA and regulate gene expression. This compound uniquely interacts with the core domain of p53, promoting its proper folding and enhancing its transcriptional activity. PRIMA-1 also influences cellular signaling pathways, potentially altering the balance between cell survival and death, thereby impacting cellular homeostasis and stress responses. | ||||||
Amifostine | 20537-88-6 | sc-200937 sc-200937A | 10 mg 50 mg | $79.00 $311.00 | 6 | |
Amifostine is a thiol compound that acts as a potent scavenger of free radicals, engaging in specific interactions with reactive oxygen species. Its unique mechanism involves the modulation of cellular redox status, which can influence various signaling pathways. By enhancing the activity of antioxidant enzymes, Amifostine plays a role in protecting cellular components from oxidative damage. Additionally, it can affect the phosphorylation state of proteins, thereby altering cellular responses to stress. | ||||||
Ascochlorin | 26166-39-2 | sc-202066 | 500 µg | $373.00 | ||
Ascochlorin is a chlorinated compound that exhibits unique interactions with cellular membranes, influencing lipid bilayer fluidity and permeability. Its distinct structural features allow it to engage in specific hydrogen bonding and hydrophobic interactions, which can modulate protein conformation and activity. Ascochlorin also participates in electron transfer processes, potentially impacting metabolic pathways and energy production within cells. Its reactivity with nucleophiles further highlights its role in cellular signaling dynamics. | ||||||