Molecular structure of HR-73, CAS Number: 959571-93-8
HR-73 (CAS 959571-93-8)
Alternate Names:
8-Bromo-1,2-dihydro-2-phenyl-3H-naphtho[2,1-b]pyran-3-one
CAS Number:
959571-93-8
Purity:
≥98%
Molecular Weight:
353.21
Molecular Formula:
C19H13BrO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
HR-73 is a splitomycin derivative and a SIRT1 inhibitor. HR-73 induces p53 hyperacetylation and decreases HIV transcription.
HR-73 (CAS 959571-93-8) References
- SIRT1 regulates HIV transcription via Tat deacetylation. | Pagans, S., et al. 2005. PLoS Biol. 3: e41. PMID: 15719057
- Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins). | Trapp, J., et al. 2007. ChemMedChem. 2: 1419-31. PMID: 17628866
- Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode. | Neugebauer, RC., et al. 2008. J Med Chem. 51: 1203-13. PMID: 18269226
- Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins). | Lawson, M., et al. 2010. Biochim Biophys Acta. 1799: 726-39. PMID: 20601279
- Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins). | Freitag, M., et al. 2011. Bioorg Med Chem. 19: 3669-77. PMID: 21315612
- Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: their evaluation as inhibitors of SIRT1. | Manjulatha, K., et al. 2012. Bioorg Med Chem Lett. 22: 6160-5. PMID: 22929231
- Current advances in the synthesis and antitumoral activity of SIRT1-2 inhibitors by modulation of p53 and pro-apoptotic proteins. | Botta, G., et al. 2012. Curr Med Chem. 19: 5871-84. PMID: 22998567
- Factors Associated With Adherence to Methylphenidate Treatment in Adult Patients With Attention-Deficit/Hyperactivity Disorder and Substance Use Disorders. | Skoglund, C., et al. 2016. J Clin Psychopharmacol. 36: 222-8. PMID: 27043119
Activator of:
p53.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HR-73, 5 mg | sc-255207 | 5 mg | $156.00 |