p34-ARC Activators
The chemical class of p34-ARC activators encompasses compounds that modulate the activity of p34-ARC, a subunit of the ARP2/3 complex, which is a critical regulator of actin filament nucleation and branching in eukaryotic cells. The protein p34-ARC is instrumental in controlling the growth of the actin cytoskeleton, thereby influencing cell shape, motility, and intracellular trafficking.
Direct p34-ARC activators would likely interact with the protein at specific binding sites, potentially inducing a conformational shift that augments the protein's ability to stimulate actin polymerization and branching. This could enhance the ARP2/3 complex's overall activity, leading to more robust and dynamic changes in the actin cytoskeleton. Such direct interaction might also stabilize the complex or increase its affinity for actin and nucleation promoting factors (NPFs), which are necessary for the formation of branched actin filament networks. Indirect activators of p34-ARC might not bind to the protein directly but could instead upregulate its expression at the transcriptional level or stabilize the protein post-translationally, leading to an accumulation of functional p34-ARC in the cell. They might also influence the post-translational modifications of p34-ARC, such as phosphorylation, which can alter the protein's activity or its interaction with other components of the ARP2/3 complex and actin.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is an activator of Protein Kinase C (PKC), which can phosphorylate and activate WASP and WAVE proteins. The activated WASP/WAVE complex binds to the Arp2/3 complex (which includes ARPC2), promoting actin nucleation. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium levels can activate the calmodulin (CaM)-dependent pathways, leading to the activation of the WASP/WAVE complex, which in turn can activate the Arp2/3 complex. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide is an actin polymerization agent, which binds to F-actin, stabilizing it and promoting actin polymerization. This process requires the Arp2/3 complex, indirectly influencing ARPC2. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D is an actin depolymerization agent. It can indirectly influence ARPC2 by promoting actin turnover, which is a process requiring Arp2/3 complex activity. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin B is an actin depolymerization agent. By disrupting actin filaments, it creates demand for new actin polymerization, a process regulated by the Arp2/3 complex. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, leading to increased cAMP levels. cAMP can activate PKA, which can in turn activate WASP/WAVE proteins, thus promoting Arp2/3 complex activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels of various proteins. This includes WASP/WAVE proteins, which are activators of Arp2/3. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases PP1 and PP2A, similarly leading to increased phosphorylation of WASP/WAVE proteins, and thus indirectly activating Arp2/3. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule depolymerization agent. Disruption of microtubules can affect actin dynamics, indirectly impacting Arp2/3 complex activity. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules, preventing their depolymerization. Changes in microtubule dynamics can indirectly affect actin polymerization and the Arp2/3 complex. | ||||||