p130 Activateurs

Les activateurs p130 courants comprennent, entre autres, la 5-azacytidine CAS 320-67-2, le resvératrol CAS 501-36-0, la trichostatine A CAS 58880-19-6, l'acide rétinoïque, tous trans CAS 302-79-4 et la curcumine CAS 458-37-7.

The p130 protein, also known as Rb2 or p130^Rb2, is a member of the retinoblastoma (Rb) family of proteins, which are primarily recognized for their role in cell cycle regulation. In the complex network of the cell cycle, these proteins act as regulatory gatekeepers, ensuring that cells only proceed to the next phase when they are fully prepared. p130, like other members of its family, interacts with E2F transcription factors and other cellular partners to modulate cell proliferation and differentiation. Essentially, the p130 protein acts as a molecular brake, interrupting cell cycle progression under specific conditions.

p130 activators refer to a chemical class of molecules that specifically target and enhance the activity of the p130 protein. By enhancing the function of p130, these activators can reinforce its natural cell cycle inhibitory actions. Mechanistically, activators can increase the protein's stability, promote its interaction with partner proteins, or enhance its ability to bind and inhibit target molecules such as E2F transcription factors. Understanding the biochemistry and molecular biology underlying these activators is essential to elucidate the complexity of the cell cycle and its regulation. As research delves deeper into the nuances of p130's roles and interactions, the complex dance of molecules in the cell continues to captivate and challenge scientists, further underscoring the importance and potential of p130 activators in cell biology.