p130 Activators
The p130 protein, also known as Rb2 or p130^Rb2, is a member of the retinoblastoma (Rb) family of proteins, which are chiefly recognized for their role in cell cycle regulation. Within the intricate network of the cell cycle, these proteins operate as key regulatory gatekeepers, ensuring that cells only progress to the next phase when they are fully prepared. p130, like other members of its family, engages in interactions with E2F transcription factors and other cellular partners to modulate cellular proliferation and differentiation. In essence, the p130 protein acts as a molecular brake, pausing cell cycle progression under specific conditions.
p130 Activators refers to a chemical class of molecules that specifically target and enhance the activity of the p130 protein. By bolstering p130's function, these activators can reinforce its natural cell cycle-inhibitory actions. Mechanistically, activators might increase the stability of the protein, promote its interaction with partner proteins, or enhance its ability to bind and inhibit target molecules, such as the E2F transcription factors. Understanding the biochemistry and molecular biology underpinning these activators is essential for unraveling the complexity of the cell cycle and its regulation. As research delves deeper into the nuances of p130's roles and its interactions, the intricate dance of molecules in the cell continues to captivate and challenge scientists, further emphasizing the importance and potential of p130 activators in cellular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor. It may upregulate p130 expression by reversing promoter hypermethylation often associated with gene silencing in cancer cells. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenolic compound found in grapes, has been shown to increase the expression of p130 in certain cellular contexts, potentially through its effects on cell cycle regulation and cellular stress pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. By changing the acetylation status of histones, it can alter the chromatin structure and thereby potentially enhance p130 gene transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a vitamin A derivative, regulates various genes through its interaction with nuclear receptors. It might influence p130 expression as part of its broad effect on cell differentiation and proliferation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a compound found in turmeric, can influence numerous signaling pathways. It might induce p130 expression as part of its effect on cell cycle regulation and apoptosis. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a soy isoflavone, has multiple targets in cells. It may enhance p130 expression through modulation of tyrosine kinases and other cell signaling pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables, sulforaphane has demonstrated the potential to modify gene expression. It might elevate p130 levels through its effects on detoxification and antioxidant pathways. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine may influence p130 expression indirectly through its known effects on the cell cycle and its role in inhibiting phosphodiesterases. | ||||||
Allyl disulfide | 2179-57-9 | sc-252359 | 25 g | $80.00 | ||
Found in garlic, diallyl disulfide has been shown to alter gene expression in certain cell types. It might modulate p130 levels as part of its broader effects on cellular proliferation and apoptosis. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
This compound, found in cruciferous vegetables, can modulate several cellular pathways. Its potential upregulation of p130 might be linked to its known effects on detoxification enzymes and hormone metabolism. | ||||||