P-Rex2 Activators
P-Rex2 activators constitute a category of chemical compounds designed to modulate the activity of the protein P-Rex2, also known as phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger 2. P-Rex2 is a member of the Rho guanine nucleotide exchange factor (RhoGEF) family and plays a critical role in cellular signal transduction pathways, particularly those involving the small GTPase Rac, which is involved in various cellular processes, including cytoskeletal dynamics, cell motility, and proliferation. P-Rex2 acts as a GEF, promoting the activation of Rac by facilitating the exchange of GDP for GTP, thereby regulating downstream signaling cascades.
P-Rex2 activators are specifically engineered to interact with P-Rex2, potentially influencing its GEF activity and modulating the activation of Rac. By targeting P-Rex2, these compounds may enhance or inhibit its ability to activate Rac, leading to downstream effects on cellular processes like cell migration, invasion, and cytoskeletal rearrangement. The study of P-Rex2 activators provides insights into the intricate mechanisms of Rac-mediated signaling and its role in various physiological and pathological contexts, contributing to a deeper understanding of cellular biology and the regulatory pathways that govern cell behavior. Further research is necessary to elucidate the precise mechanisms of action and potential biological outcomes associated with P-Rex2 activation in different cellular contexts, offering valuable insights into cellular physiology and the modulation of signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates PI3K/Akt signaling, leading to increased PIP3 levels. The presence of PIP3 might upregulate or activate P-Rex2 expression or function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises cAMP levels, which can influence various gene expressions, potentially including P-Rex2. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine might modulate the expression of genes involved in cell motility, including P-Rex2. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid affects cellular differentiation and might influence the expression of proteins related to cell migration, potentially including P-Rex2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR signaling. Since mTOR can regulate various cellular processes, it might indirectly influence P-Rex2 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has various cellular effects. It might modulate the expression of proteins related to cell motility, potentially including P-Rex2. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS stimulates inflammatory responses and can activate various cellular pathways, potentially influencing P-Rex2 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin affects multiple cellular pathways and might modulate the expression of proteins involved in cell migration, potentially including P-Rex2. | ||||||