P/Q-type calcium channel α1A Activators
P/Q-type calcium channel α1A Activators are a varied collection of compounds that enhance the channel's functionality by indirectly influencing the calcium dynamics within neurons. Bay K 8644 indirectly increases the activity of P/Q-type calcium channel α1A by stimulating L-type calcium channels, leading to an overall increase in cellular calcium influx, which can prime the voltage-dependent P/Q-type channels for activation during depolarization. Additionally, blocking agents for other calcium channel subtypes, such as Nifedipine, Nitrendipine, and Amlodipine, which target L-type channels, along with Ethosuximide, which inhibits T-type channels, may provoke a compensatory upregulation of P/Q-type channel activity to stabilize calcium signaling. FPL 64176, by decelerating the inactivation of calcium channels, could also contribute to extending the active state of P/Q-type calcium channel α1A. Furthermore, sub-blocking doses of toxins like ω-Agatoxin IVA may sensitize the P/Q-type channels to voltage changes, thereby facilitating their activation.
The activity of P/Q-type calcium channel α1A is further modulated by agents that alter the activity of closely related ion channels or intracellular kinases. ω-Conotoxin GVIA and SNX-482, which selectively inhibit N-type and R-type calcium channels, respectively, can indirectly potentiate P/Q-type channel activity as neurons adjust to the altered calcium entry landscape. Compounds like ω-Conotoxin MVIIC, which can block both P/Q-type and N-type channels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
A dihydropyridine compound that acts as an L-type calcium channel agonist, indirectly increasing the activity of P/Q-type calcium channels by promoting a cellular environment rich in intracellular calcium, which can increase the demand for calcium influx through P/Q-type channels. | ||||||
ω-Agatoxin IVA | 145017-83-0 | sc-302015 | 100 µg | $454.00 | ||
A selective P/Q-type calcium channel blocker that at sub-blocking concentrations could enhance channel activity by stabilizing the open state of the channel. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
A cyclin-dependent kinase inhibitor that may indirectly enhance P/Q-type calcium channel function by altering cell cycle and signaling pathways that regulate channel phosphorylation and surface expression. | ||||||
PD 153035 | 153436-54-5 | sc-205909 | 5 mg | $146.00 | 5 | |
An EGFR tyrosine kinase inhibitor that may indirectly enhance P/Q-type calcium channel function by altering downstream signaling pathways that modulate calcium channel activity. | ||||||
Nimodipine | 66085-59-4 | sc-201464 sc-201464A | 100 mg 1 g | $60.00 $301.00 | 2 | |
An L-type calcium channel blocker that, at low concentrations or in specific contexts, may enhance P/Q-type calcium channel activity by shifting cellular calcium homeostasis. | ||||||
Mibefradil dihydrochloride | 116666-63-8 | sc-204083 sc-204083A | 10 mg 50 mg | $209.00 $848.00 | 4 | |
A T-type calcium channel blocker with effects on other calcium channels that may increase the functional activity of P/Q-type calcium channels under certain conditions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
A potent activator of protein kinase C (PKC) which can phosphorylate and enhance the activity of P/Q-type calcium channels. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Another dihydropyridine calcium channel blocker that, through its actions on L-type channels, may indirectly increase the functional demand for P/Q-type calcium channels in certain neuronal contexts. | ||||||
Isradipine | 75695-93-1 | sc-201467 sc-201467A | 10 mg 50 mg | $86.00 $318.00 | 1 | |
A calcium channel blocker selective for L-type channels that, through its vasodilatory effects, could alter local blood flow and thus indirectly modulate neuronal P/Q-type calcium channel activity. | ||||||