Ovarian Carcinoma-associated Antigen Activators
Ovarian Carcinoma-associated Antigen, commonly referred to as CA-125 or MUC16, is a well-known biomarker used in the monitoring of ovarian cancer progression. This protein is a mucin that is expressed at relatively low levels in normal tissues but is often overexpressed in ovarian carcinoma cells. The expression of CA-125 is not exclusive to malignant cells; it can also be elevated in benign conditions, making it a sensitive, but not specific, marker. The regulation of CA-125 expression is complex and can be influenced by a variety of endogenous and exogenous factors, including hormonal fluctuations and cellular stress responses.
A diverse array of chemicals has the potential to induce the expression of CA-125, through direct or indirect interactions with cellular machinery. Compounds such as retinoic acid, a metabolite of vitamin A, may upregulate CA-125 expression as part of the cell differentiation processes in the ovaries. DNA methyltransferase inhibitors like 5-Azacytidine could stimulate the expression of CA-125 by reducing methylation levels at the promoter regions of its gene, thus allowing transcription to proceed. Synthetic and natural compounds that interact with hormone receptors, such as Diethylstilbestrol and Bisphenol A, might also increase CA-125 production due to their estrogenic or endocrine-disrupting activities. Furthermore, agents that cause cellular stress, like Cisplatin or Etoposide, which are known to induce DNA damage, could lead to an upregulation of CA-125 as part of the cellular stress response. The intricate interplay between these chemicals and the cellular environment underscores the delicate balance of gene expression regulation, which includes the expression of Ovarian Carcinoma-associated Antigen. This complexity provides insight into the molecular dance that orchestrates cellular responses to internal and external stimuli, shedding light on the myriad ways in which gene expression can be modulated.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid might upregulate the transcription of the Ovarian Carcinoma-associated Antigen gene by binding to retinoic acid receptors, which can act as transcription factors in the regulation of gene expression related to cell differentiation in ovarian cells. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor could hypothetically induce the expression of Ovarian Carcinoma-associated Antigen by reducing methylation at the promoter region of its gene, leading to a more open chromatin state and increased transcription. | ||||||
Diethylstilbestrol | 56-53-1 | sc-204720 sc-204720A sc-204720B sc-204720C sc-204720D | 1 g 5 g 25 g 50 g 100 g | $71.00 $287.00 $547.00 $1098.00 $2185.00 | 3 | |
Diethylstilbestrol has the potential to stimulate the expression of Ovarian Carcinoma-associated Antigen by mimicking the action of estrogens and binding to estrogen receptors, which might then bind to estrogen response elements on the gene responsible for CA-125 production. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
Tamoxifen could theoretically increase the expression of Ovarian Carcinoma-associated Antigen in certain ovarian cancer subtypes that respond to hormonal signaling, due to its partial agonist activity on estrogen receptors in these tissues. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin may induce the expression of Ovarian Carcinoma-associated Antigen through the activation of various signal transduction pathways following DNA damage, which can lead to the transcriptional activation of DNA repair genes and stress response genes. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol could stimulate the expression of Ovarian Carcinoma-associated Antigen by interfering with normal microtubule breakdown during cell division, causing cell cycle arrest and potentially triggering a stress-induced increase in gene expression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide may lead to an increase in Ovarian Carcinoma-associated Antigen expression as a cellular response to DNA strand breaks that this compound induces, triggering the DNA damage response machinery. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate could potentially upregulate Ovarian Carcinoma-associated Antigen expression by inhibiting the growth of ovarian cancer cells through its antioxidant properties, leading to compensatory mechanisms that include increased expression of tumor markers. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A could theoretically stimulate the increased production of Ovarian Carcinoma-associated Antigen by acting as an estrogen mimic, binding to estrogen receptors, and activating the transcription of estrogen-responsive genes in ovarian cells. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate might induce the expression of Ovarian Carcinoma-associated Antigen by causing folate deficiency at the cellular level, which could lead to compensatory upregulation of proteins associated with cell survival and proliferation pathways. | ||||||