OTTMUSG00000016789 Inhibitors
Histone H2A-like 1 plays a crucial role in the structure and function of chromatin, primarily through its involvement in chromatin compaction and gene regulation. The chemical inhibitors listed, all being histone deacetylase inhibitors, target this protein by altering its acetylation state, which in turn affects chromatin architecture and function. Trichostatin A, for example, prevents the removal of acetyl groups from histone proteins, leading to a relaxed chromatin structure. This relaxed state interferes with the normal functioning of histone H2A-like 1 in maintaining a compact chromatin structure, which is essential for regulated gene expression. Similarly, Sodium Butyrate, by inhibiting deacetylation, elevates the levels of acetylated histones, including histone H2A-like 1. This alteration changes the chromatin structure, impacting histone H2A-like 1's ability to control gene expression through chromatin remodeling.
Continuing with other inhibitors like Vorinostat, Panobinostat, and Valproic Acid, these chemicals also act as histone deacetylase inhibitors, leading to an increased acetylation of histone H2A-like 1. The consequence of this elevated acetylation is a more open chromatin conformation, which is less conducive to the normal role of histone H2A-like 1 in chromatin organization and gene regulation. Inhibitors such as Romidepsin and Belinostat function similarly, maintaining higher levels of acetylation on histone proteins, thus affecting the chromatin structure and the role of histone H2A-like 1 in it. Entinostat, Tacedinaline, Quisinostat, Mocetinostat, and Givinostat, all work by the same mechanism of inhibiting histone deacetylase, leading to changes in the chromatin structure through increased histone acetylation. This change in the chromatin architecture affects the functionality of histone H2A-like 1 in chromatin remodeling and gene expression control. The consistent theme across these inhibitors is their ability to disrupt the normal compact structure of chromatin, which is crucial for the functional role of histone H2A-like 1, thereby inhibiting its ability to effectively participate in chromatin organization and gene regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. It inhibits the removal of acetyl groups from histone proteins, leading to increased acetylation. Histone H2A-like 1, being a variant of histone H2A, is involved in the packaging of DNA into chromatin. Increased acetylation caused by Trichostatin A results in a more relaxed chromatin structure, which can interfere with the normal functioning of histone H2A-like 1 in chromatin compaction and gene regulation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate acts as a histone deacetylase inhibitor, similar to Trichostatin A. By inhibiting deacetylation, it leads to higher levels of acetylated histones, including variants like histone H2A-like 1. This modification alters chromatin structure, leading to a more open chromatin conformation and impacting the ability of histone H2A-like 1 to perform its normal role in chromatin remodeling and gene expression regulation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid, another histone deacetylase inhibitor, functions by preventing the removal of acetyl groups from histone proteins. This action results in increased acetylation of histones, including histone H2A-like 1. The increased acetylation disrupts the normal compact chromatin structure, impairing histone H2A-like 1's role in chromatin organization and gene regulation. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat is a broad-spectrum histone deacetylase inhibitor. By inhibiting the deacetylation process, it leads to increased acetylation of histone proteins, including histone H2A-like 1. This alteration in histone acetylation levels affects the chromatin structure, impacting the functional role of histone H2A-like 1 in maintaining chromatin integrity and regulating gene expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid, primarily known as a mood stabilizer, also acts as a histone deacetylase inhibitor. It leads to increased acetylation of histones, including histone H2A-like 1, by inhibiting their deacetylation. This increased acetylation changes the chromatin structure, affecting histone H2A-like 1's role in chromatin organization and gene expression control. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin is a histone deacetylase inhibitor that increases acetylation levels of histone proteins. This alteration in acetylation affects the chromatin structure, impacting the functionality of histone H2A-like 1 in terms of chromatin compaction and gene regulation. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
Belinostat, a histone deacetylase inhibitor, functions by maintaining higher levels of acetylation on histone proteins. This increased acetylation impacts the chromatin structure, affecting the role of histone H2A-like 1 in chromatin remodeling and gene expression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
MS-275, as a histone deacetylase inhibitor, leads to increased acetylation of histone proteins, including histone H2A-like 1. This results in a more open chromatin structure, impacting histone H2A-like 1's functionality in chromatin organization and gene expression regulation. | ||||||
CI 994 | 112522-64-2 | sc-205245 sc-205245A | 10 mg 50 mg | $99.00 $536.00 | 1 | |
CI 994 is a histone deacetylase inhibitor that increases the acetylation levels of histones. This change in histone acetylation impacts the structural organization of chromatin, affecting the role of histone H2A-like 1 in chromatin compaction and gene expression control. | ||||||
JNJ-26481585 | 875320-29-9 | sc-364515 sc-364515A | 5 mg 50 mg | $321.00 $1224.00 | ||
JNJ-26481585, a histone deacetylase inhibitor, enhances acetylation of histone proteins, including histone H2A-like 1. This alteration in acetylation levels changes the chromatin structure, thereby impacting the functionality of histone H2A-like 1 in chromatin organization and gene expression regulation. | ||||||