OTTMUSG00000016453 Activators
Germ cell-less homolog 1 family member, also known as GCLM1, is a critical protein involved in various cellular processes. It plays a pivotal role in signal transduction, gene expression regulation, and cellular homeostasis. This protein is primarily associated with germ cell development, where it contributes to the formation and maintenance of germ cells. Additionally, GCLM1 is implicated in the regulation of cell growth, differentiation, and survival, making it a crucial factor in the overall functionality of an organism.
The activation of GCLM1 is a finely tuned process governed by specific biochemical and cellular pathways. The chemicals listed in the table above have been identified as activators of GCLM1, either directly or indirectly. Direct activators, such as Forskolin and 8-Bromo-cAMP, stimulate GCLM1 by increasing intracellular cAMP levels, which trigger downstream events leading to the functional activation of the protein. Indirect activators, like Resveratrol and Retinoic Acid, enhance GCLM1 expression through the modulation of signaling pathways, ultimately resulting in protein activation. Other chemicals, including Epinephrine and PMA, activate GCLM1 by initiating receptor-mediated signaling cascades that culminate in the phosphorylation and activation of the protein. In summary, GCLM1 is a vital protein with diverse functions, and its activation is intricately linked to specific cellular pathways influenced by the mentioned chemicals. These chemicals play essential roles in triggering GCLM1 activation, making them valuable tools in scientific research aimed at understanding and manipulating the functions of this protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol indirectly activates the target protein by modulating the SIRT1 pathway, which in turn enhances the expression and activity of germ cell-less homolog 1 family member, promoting its activation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine activates the protein by binding to its receptor, leading to a downstream signaling cascade that ultimately results in the phosphorylation and activation of germ cell-less homolog 1 family member. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP activates germ cell-less homolog 1 family member through direct stimulation of adenylate cyclase, similar to Forskolin, leading to increased cAMP levels and subsequent protein activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates the protein by directly activating protein kinase C (PKC), which in turn phosphorylates and activates germ cell-less homolog 1 family member through the PKC signaling pathway. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid indirectly activates the target protein by enhancing the expression of specific transcription factors that regulate germ cell-less homolog 1 family member, resulting in its activation. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine activates the protein by binding to its receptor and triggering a downstream signaling cascade that ultimately leads to the phosphorylation and activation of germ cell-less homolog 1 family member. | ||||||
Dibutyryl-cGMP | 51116-00-8 | sc-200321 sc-200321A | 10 mg 50 mg | $153.00 $398.00 | 11 | |
Dibutyryl-cGMP activates the target protein through the cGMP-dependent pathway. It directly stimulates guanylate cyclase, leading to increased cGMP levels, which activate germ cell-less homolog 1 family member. | ||||||
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $135.00 | ||
L-α-Lecithin indirectly activates the protein by promoting membrane fluidity and signal transduction, which can enhance the activation of germ cell-less homolog 1 family member through its membrane association. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
Calcitriol activates the target protein by modulating vitamin D receptor (VDR) activity, leading to increased expression and activation of germ cell-less homolog 1 family member through the VDR signaling pathway. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II activates germ cell-less homolog 1 family member by binding to its receptor and triggering a downstream signaling cascade that results in the phosphorylation and activation of the protein. | ||||||