OTTMUSG00000011265 Activators
Gm13272 plays a pivotal role in cellular responses to external stimuli and signal transduction. Activation of Gm13272 is primarily achieved through phosphorylation events, leading to its functional activation. Several chemicals listed in the table above can activate Gm13272, either directly or indirectly, by modulating specific signaling pathways. Direct activators like Forskolin and Phorbol 12-myristate 13-acetate (PMA) directly engage with intracellular components to trigger phosphorylation cascades that culminate in the activation of Gm13272. Meanwhile, indirect activators like Epidermal Growth Factor (EGF) and Retinoic Acid (RA) act by stimulating upstream receptors and subsequent signaling pathways, indirectly influencing Gm13272's activity.
Furthermore, some chemicals, such as Dihydrotestosterone (DHT) and Retinol, exert their influence on Gm13272 by modulating gene expression. They enhance the expression of genes involved in the target protein's signaling pathway, leading to increased pathway activity and, ultimately, the functional activation of Gm13272. In summary, Gm13272 is a vital protein in cellular signaling, and its activation is essential for various cellular processes. Chemical activators, both direct and indirect, play a crucial role in regulating its activity by influencing specific signaling pathways or gene expression patterns. Understanding these activation mechanisms is fundamental in deciphering the intricate cellular processes in which Gm13272 is involved.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
DMSO activates Gm13272 by serving as a solvent for various small molecules, facilitating their entry into cells. This enhances the intracellular concentration of potential activators, promoting functional activation of the target protein. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Gm13272 indirectly by activating protein kinase C (PKC). PKC activation triggers a downstream signaling cascade, ultimately leading to the phosphorylation and functional activation of the target protein. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin indirectly activates Gm13272 by inducing calcium influx into cells. Increased intracellular calcium levels activate calcium/calmodulin-dependent protein kinases (CaMK), which can phosphorylate and activate the target protein, resulting in functional activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
RA indirectly activates Gm13272 by modulating gene expression. It upregulates specific genes that encode proteins involved in the activation of the target protein's signaling pathway. This results in the functional activation of Gm13272 through the enhanced expression of pathway components. | ||||||
Vitamin A | 68-26-8 | sc-280187 sc-280187A | 1 g 10 g | $385.00 $2654.00 | ||
Vitamin A indirectly activates Gm13272 by serving as a precursor for retinoic acid (RA) synthesis. RA, in turn, modulates gene expression to enhance the activity of the target protein's signaling pathway, leading to its functional activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin indirectly activates Gm13272 by depleting intracellular calcium stores. This leads to calcium release from the endoplasmic reticulum and activates CaMKs, which phosphorylate and activate the target protein, resulting in its functional activation. | ||||||
all-trans Retinal | 116-31-4 | sc-210778A sc-210778 | 250 mg 1 g | $129.00 $379.00 | 7 | |
RAL indirectly activates Gm13272 by being converted to retinoic acid (RA) in cells. RA, as mentioned earlier, modulates gene expression to enhance the activity of the target protein's signaling pathway, ultimately resulting in its functional activation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 indirectly activates Gm13272 by binding to its receptor EP4. EP4 receptor activation triggers intracellular signaling pathways, including the cAMP-PKA pathway, which can phosphorylate and activate the target protein, leading to its functional activation. | ||||||