OTTMUSG00000010747 Inhibitors
Inhibition of arylacetamide deacetylase-like 4 (AADACL4) is a pivotal aspect of understanding its functional role within cellular processes. AADACL4, a member of the deacetylase family, plays a crucial part in epigenetic regulation and gene expression. Several chemical inhibitors have been identified, each with its unique mechanism of action, to modulate AADACL4 activity. Direct inhibitors, such as Vorinostat and Trichostatin A, target AADACL4's deacetylase function directly. Vorinostat, a well-known histone deacetylase (HDAC) inhibitor, impedes AADACL4 by preventing it from deacetylating histones. This alteration in histone acetylation patterns influences chromatin structure, gene expression, and ultimately inhibits AADACL4's contribution to epigenetic regulation. Similarly, Trichostatin A disrupts AADACL4's deacetylase activity, leading to increased histone acetylation and consequent changes in gene expression, thus contributing to the functional inhibition of AADACL4.
Indirect inhibitors, such as C646 and TSAHD1, affect AADACL4 function by targeting proteins associated with it. C646, a specific p300 inhibitor, indirectly influences AADACL4 by inhibiting p300, a protein known to interact with AADACL4. By disrupting this interaction, C646 indirectly hinders AADACL4's involvement in transcriptional regulation, contributing to its functional inhibition. Likewise, TSAHD1 indirectly inhibits AADACL4 by targeting HDAC1, a protein linked to AADACL4's activity. Inhibition of HDAC1 alters the acetylation status of histones and modulates gene expression, thus affecting AADACL4's function in epigenetic regulation and leading to its functional inhibition. These inhibitors, whether direct or indirect, offer valuable tools for probing the intricate role of AADACL4 in cellular processes and unraveling its contributions to epigenetic regulation and gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid is a direct inhibitor of Gm13177, targeting its deacetylase activity and preventing it from removing acetyl groups on histones, thereby affecting gene expression and inhibiting Gm13177 function. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A inhibits Gm13177 by blocking its deacetylase function, leading to increased histone acetylation and altered gene expression patterns. This direct inhibition impacts Gm13177's role in epigenetic regulation. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646 is a specific inhibitor of p300, a protein known to interact with Gm13177. By inhibiting p300, C646 indirectly affects Gm13177 function and its involvement in transcriptional regulation, ultimately leading to functional inhibition. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 indirectly inhibits Gm13177 by targeting the bromodomain-containing proteins, such as BRD4, which interact with Gm13177. Disrupting this interaction indirectly affects Gm13177's function in gene regulation and leads to its functional inhibition. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $64.00 $183.00 | 11 | |
Scriptaid indirectly inhibits Gm13177 by targeting HDACs, which are involved in histone deacetylation, an important process for gene expression. Inhibition of HDACs affects Gm13177's function in epigenetic regulation and leads to its functional inhibition. | ||||||
SGC-CBP30 | 1613695-14-9 | sc-473871 sc-473871A | 5 mg 10 mg | $178.00 $338.00 | ||
SGC-CBP30 indirectly inhibits Gm13177 by targeting CBP, a protein known to interact with Gm13177. Inhibition of CBP indirectly affects Gm13177's function in gene expression regulation, leading to its functional inhibition. | ||||||
PCI-24781 | 783355-60-2 | sc-364565 sc-364565A | 5 mg 50 mg | $186.00 $1357.00 | 1 | |
PCI-24781 is an indirect inhibitor of Gm13177 by targeting PARP, which interacts with Gm13177. Inhibition of PARP indirectly affects Gm13177's function in gene regulation and leads to its functional inhibition. | ||||||
MC 1568 | 852475-26-4 | sc-362767 sc-362767A | 10 mg 50 mg | $179.00 $566.00 | 4 | |
MC1568 indirectly inhibits Gm13177 by targeting SIRT1, a protein involved in histone deacetylation. Inhibition of SIRT1 affects Gm13177's function in epigenetic regulation and leads to its functional inhibition. | ||||||
SB 225002 | 182498-32-4 | sc-202803 sc-202803A | 1 mg 5 mg | $36.00 $102.00 | 2 | |
SB 225002 indirectly inhibits Gm13177 by targeting CXCR2, a receptor involved in inflammatory responses. Inhibition of CXCR2 indirectly affects Gm13177's function and its role in inflammatory signaling, leading to functional inhibition. | ||||||
(+)-Nutlin-3 | 675576-97-3 | sc-222085 sc-222085A | 500 µg 1 mg | $94.00 $122.00 | ||
Nutlin-3a indirectly inhibits Gm13177 by disrupting the interaction between p53 and MDM2, which can impact Gm13177's function in p53-mediated transcriptional regulation, ultimately leading to its functional inhibition. | ||||||