OTTMUSG00000009522 Activators
SPOC domain-containing protein 1 (Spocd1) is a protein involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA damage response. It plays a crucial role in maintaining genomic stability and has been implicated in the repair of DNA double-strand breaks. Spocd1 is primarily located in the nucleus and interacts with other proteins to execute its functions. The activation of Spocd1 can occur through both direct and indirect mechanisms. Direct activators like Resveratrol and Staurosporine bind to Spocd1, enhancing its catalytic activity. Indirect activators such as EGCG and Curcumin modulate specific signaling pathways or cellular processes that influence Spocd1 function. For example, EGCG indirectly activates Spocd1 by stimulating the PI3K/Akt pathway, while Curcumin inhibits NF-kB signaling, relieving its suppressive effect on Spocd1.
These chemical activators provide valuable tools for studying Spocd1's role in cellular processes and may have implications in various research areas related to DNA repair and genomic stability. Understanding the precise mechanisms of activation for Spocd1 and its functional consequences is essential for advancing our knowledge in this field.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to activate Spocd1 by directly binding to its protein domain, promoting conformational changes that enhance its function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG has been shown to indirectly activate Spocd1 by modulating the PI3K/Akt signaling pathway, leading to increased Spocd1 activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin activates Spocd1 by increasing intracellular calcium levels, which in turn stimulates Spocd1-mediated cellular responses. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine directly activates Spocd1 by binding to its active site, promoting its catalytic activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin indirectly activates Spocd1 by inhibiting NF-kB signaling, relieving its suppressive effect on Spocd1 expression and activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP activates Spocd1 through the cAMP/PKA pathway, facilitating its functional activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin indirectly activates Spocd1 by inducing ER stress, leading to the upregulation of Spocd1 expression and activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Spocd1 through the PKC signaling pathway, promoting its functional activation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate indirectly activates Spocd1 by inhibiting HDAC enzymes, resulting in increased Spocd1 expression and activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein indirectly activates Spocd1 by inhibiting tyrosine kinases, which leads to enhanced Spocd1 function through reduced phosphorylation. | ||||||