OTTMUSG00000004968 Activators
Krtap2-4-like, a protein encoded by the Gm11938 gene, plays a crucial role in various cellular processes, particularly in hair and skin development. This protein belongs to the keratin-associated protein (KRTAP) family and is essential for maintaining the structural integrity and function of hair fibers. Krtap2-4-like is predominantly expressed in the hair follicles and is involved in the formation of keratin intermediate filaments, which are integral for the strength and flexibility of hair shafts. The activation of Krtap2-4-like is intricately regulated by various chemical agents that influence specific cellular pathways. The identified chemicals, such as Resveratrol, Forskolin, and Dihydrocapsaicin, functionally activate Krtap2-4-like by modulating key signaling pathways. These pathways include SIRT1-mediated deacetylation, cAMP-PKA pathway activation, and TRPV1 receptor-induced calcium influx. Furthermore, epigenetic modifiers like Quercetin and Sodium Valproate enhance Krtap2-4-like gene expression by modifying histone acetylation patterns, promoting an open chromatin structure favorable for transcription.
Additionally, compounds such as Oleanolic Acid and Tretinoin indirectly activate Krtap2-4-like by participating in the Nrf2-ARE pathway and retinoic acid receptor-mediated transcriptional regulation, respectively. Sodium Butyrate and 2-Deoxy-D-glucose exert their effects by inhibiting histone deacetylases and activating AMP-activated protein kinase (AMPK), leading to enhanced expression of Krtap2-4-like. α-Lipoic Acid, with its role in the Nrf2 pathway, and 5-Azacytidine, through DNA demethylation, also contribute to the functional activation of Krtap2-4-like. Lastly, Genistein, by interacting with estrogen receptors, induces transcriptional activation of Krtap2-4-like in estrogen-responsive tissues. In summary, Krtap2-4-like is a critical protein in hair and skin development, and its activation is intricately regulated by various chemical agents that modulate specific signaling pathways and epigenetic modifications. These chemicals play a crucial role in maintaining the structural integrity and function of hair fibers, offering potential avenues for further research into hair-related disorders.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates Krtap2-4-like by enhancing the SIRT1 pathway, leading to deacetylation of specific transcription factors and subsequent increased Krtap2-4-like gene expression. | ||||||
Dihydrocapsaicin | 19408-84-5 | sc-202578 sc-202578A | 10 mg 50 mg | $52.00 $156.00 | 1 | |
Dihydrocapsaicin activates the TRPV1 receptor, leading to an influx of calcium ions that activate calcium-dependent kinases. These kinases phosphorylate transcription factors associated with Krtap2-4-like, promoting its gene expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin acts as a histone deacetylase inhibitor, increasing histone acetylation near the Krtap2-4-like gene promoter. This epigenetic modification enhances gene transcription. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Sodium Valproate modulates histone acetylation, favoring a more relaxed chromatin structure around the Krtap2-4-like gene, facilitating its transcriptional activation. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $86.00 $302.00 | 8 | |
Oleanolic Acid activates the Nrf2-ARE pathway, which induces the expression of antioxidative enzymes. This indirectly activates Krtap2-4-like by reducing oxidative stress and promoting its function. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid, all trans interacts with retinoic acid receptors (RARs), leading to their translocation to the nucleus and binding to retinoic acid response elements (RAREs) near the Krtap2-4-like gene, enhancing its expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate inhibits histone deacetylases (HDACs), increasing histone acetylation at the Krtap2-4-like promoter and promoting gene transcription. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose affects the glycolytic pathway, leading to the activation of AMP-activated protein kinase (AMPK). AMPK phosphorylates transcription factors involved in Krtap2-4-like gene regulation, enhancing its expression. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
α-Lipoic Acid activates the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, resulting in increased expression of antioxidative enzymes and indirectly activating Krtap2-4-like by reducing oxidative stress. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA demethylating agent that can reverse hypermethylation at the Krtap2-4-like gene promoter, allowing for increased gene expression. | ||||||