OR9G1 Activators
OR9G1 encompass a range of compounds that interface with cellular signaling pathways, ultimately leading to the modulation of OR9G1 activity via phosphorylation. Forskolin serves as a direct stimulant of adenylyl cyclase, which catalyzes the conversion of ATP to cAMP, a secondary messenger that activates protein kinase A (PKA). Upon activation, PKA can phosphorylate OR9G1, thereby modifying its function. Isoproterenol, a beta-adrenergic agonist, and Epinephrine, another adrenergic receptor target, also enhance adenylyl cyclase activity, similarly elevating cAMP levels and activating PKA, which in turn can phosphorylate OR9G1. Dopamine and Adenosine interact with their specific G protein-coupled receptors, D1-like and A2A/A2B respectively, to activate adenylyl cyclase and the subsequent cAMP-PKA signaling cascade, which can lead to the phosphorylation of OR9G1.
In addition to compounds that increase cAMP levels, several chemicals inhibit the breakdown of this secondary messenger, thereby sustaining or enhancing PKA activation and subsequent phosphorylation of OR9G1. IBMX and Rolipram are notable for their inhibition of phosphodiesterases (PDEs), with IBMX acting non-selectively and Rolipram targeting PDE4 specifically. This inhibition prevents the degradation of cAMP within the cell, facilitating sustained PKA activity. Prostaglandin E2 (PGE2) engages with G protein-coupled receptors to activate adenylyl cyclase, and Histamine, through H2 receptors, amplifies cAMP levels. Both pathways converge on PKA activation, which can phosphorylate OR9G1. Similarly, Glucagon binds to its receptor to activate adenylyl cyclase, leading to increased cAMP and PKA activation, potentially resulting in OR9G1 phosphorylation. Lastly, Salbutamol, a selective beta-2 adrenergic receptor agonist, elevates cAMP levels, again activating PKA and possibly leading to phosphorylation of OR9G1. Each of these chemicals, through their unique interactions with cellular enzymes and receptors, contribute to the regulation of OR9G1 activity within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic catecholamine that functions as a non-selective beta-adrenergic agonist. By activating beta-adrenergic receptors, it stimulates adenylyl cyclase activity, thereby increasing cAMP production. This amplification in cAMP can activate PKA, which may phosphorylate and enhance the activity of OR9G1, given that OR9G1 is a substrate for PKA. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases (PDEs). By inhibiting PDEs, it prevents the breakdown of cAMP and cGMP, leading to their accumulation in the cell. The increased levels of cAMP can activate PKA, which in turn can phosphorylate and activate OR9G1, assuming OR9G1 is susceptible to regulation by PKA-mediated phosphorylation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) interacts with its G protein-coupled receptors (GPCRs), which can lead to the activation of adenylyl cyclase and an increase in cAMP levels. The subsequent activation of PKA can result in the phosphorylation and activation of OR9G1, provided that OR9G1 is a protein that can be activated by PKA-dependent phosphorylation. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine, through its action on H2 receptors, a subtype of histamine receptors, increases intracellular cAMP levels by activating adenylyl cyclase. The rise in cAMP activates PKA, which could phosphorylate and activate OR9G1 if OR9G1 is within the array of PKA targets. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can bind to D1-like dopamine receptors, which are coupled to Gs proteins, leading to the activation of adenylyl cyclase and increased cAMP levels. This elevation in cAMP can activate PKA, which may target and activate OR9G1 through phosphorylation, assuming OR9G1 is a PKA substrate. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine interacts with A2A and A2B adenosine receptors, which are linked to Gs proteins. This interaction activates adenylyl cyclase, which increases cAMP levels and thereby activates PKA. PKA can then potentially phosphorylate and activate OR9G1, provided OR9G1 is a protein that can be activated through PKA-mediated phosphorylation processes. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, through its action on beta-adrenergic receptors, leads to the activation of adenylyl cyclase and an increase in intracellular cAMP. This increase in cAMP activates PKA, which may phosphorylate and activate OR9G1, assuming OR9G1 is a PKA substrate. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which leads to an accumulation of cAMP within cells. The elevated cAMP levels can result in the activation of PKA, which could phosphorylate and activate OR9G1, assuming OR9G1 is a target for PKA. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
Salbutamol is a selective beta-2 adrenergic receptor agonist that stimulates adenylyl cyclase activity, leading to increased cAMP levels. The increased cAMP activates PKA, which could phosphorylate and activate OR9G1, provided that OR9GIt seems that your request was cut off before you could finish providing the details or asking a question. Please provide the full context or your question so I can assist you appropriately. | ||||||