OR8H3 Activators
OR8H3 can initiate a cascade of intracellular events leading to its activation. Isoproterenol, a synthetic beta-adrenergic agonist, engages with its corresponding receptors, triggering a signaling pathway that results in the activation of adenylate cyclase. This enzyme catalyzes the conversion of ATP to cAMP, a secondary messenger that plays a pivotal role in cellular signaling. The accumulation of cAMP in the cytoplasm can activate protein kinase A (PKA), which is capable of phosphorylating a variety of cellular proteins, including OR8H3. Similarly, forskolin, a diterpene, acts directly on adenylate cyclase, bypassing receptor engagement and leading to an upsurge in cAMP and subsequent activation of PKA, which then can phosphorylate OR8H3. IBMX, meanwhile, prevents the degradation of cAMP by inhibiting phosphodiesterases, thus sustaining PKA in its active form to phosphorylate OR8H3.
Epinephrine and norepinephrine, both catecholamines, stimulate adrenergic receptors, which signal through G proteins to increase adenylate cyclase activity. This elevation in cAMP levels promotes PKA activation, which in turn phosphorylates OR8H3. Histamine, interacting with H2 receptors, and dopamine, through dopamine receptors, also enhance adenylate cyclase activity, subsequently raising cAMP levels and activating PKA, leading to the phosphorylation of OR8H3. Adenosine and PGE2, by binding to their respective receptors, activate adenylate cyclase, which increases cAMP and activates PKA, resulting in OR8H3 phosphorylation. Similarly, PACAP and glucagon, by engaging with their specific receptors, stimulate adenylate cyclase, leading to a rise in cAMP and PKA activation, which then can phosphorylate OR8H3. Lastly, cholera toxin, by permanently activating the Gs alpha subunit, leads to continuous activation of adenylate cyclase, causing chronic elevation of cAMP levels and sustained PKA activation, which subsequently phosphorylates OR8H3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic compound that acts as an agonist for beta-adrenergic receptors, leading to the activation of adenylate cyclase and a subsequent increase in cyclic AMP (cAMP) levels within the cell. Elevated cAMP may lead to the activation of protein kinase A (PKA), which could phosphorylate and thereby activate OR8H3 through phosphorylation-dependent mechanisms. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX, or 3-Isobutyl-1-methylxanthine, is a non-selective inhibitor of phosphodiesterases, enzymes that break down cAMP. By inhibiting these enzymes, IBMX raises intracellular cAMP levels, which may lead to PKA activation. PKA can then potentially phosphorylate OR8H3, leading to its activation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to adrenergic receptors on the cell surface, which can activate adenylate cyclase and increase intracellular cAMP levels. This cascade can lead to the activation of PKA, which may phosphorylate OR8H3, leading to its activation. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Norepinephrine, like epinephrine, engages adrenergic receptors that stimulate adenylate cyclase activity, resulting in higher levels of cAMP. The rise in cAMP can activate PKA, which in turn could phosphorylate and activate OR8H3. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine can bind to H2 receptors that are coupled to adenylate cyclase via Gs proteins, leading to an increase in cAMP levels. The elevation in cAMP may activate PKA, which could phosphorylate and thus activate OR8H3. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine interacts with dopamine receptors that can activate adenylate cyclase, causing an increase in cAMP concentration. This can lead to PKA activation, which may result in the phosphorylation and activation of OR8H3. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine binds to certain adenosine receptors, which can activate adenylate cyclase and lead to increased cAMP levels. This can activate PKA, which may then phosphorylate and activate OR8H3. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) interacts with its G-protein-coupled receptors, which can lead to adenylate cyclase activation and an increase in cAMP levels. Through the activation of PKA, PGE2 may promote the phosphorylation and activation of OR8H3. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Pituitary adenylate cyclase-activating polypeptide (PACAP) binds to its receptors, stimulating adenylate cyclase and increasing cAMP. The subsequent activation of PKA could lead to the phosphorylation and activation of OR8H3. | ||||||