OR8B8 Inhibitors
OR8B8 inhibitors are chemical compounds that specifically interact with and block the activity of the OR8B8 olfactory receptor, a member of the G protein-coupled receptor (GPCR) family. These inhibitors function by binding to key regions of the receptor, typically its active or allosteric sites, thus preventing its natural ligand, usually odor molecules, from binding and activating it. OR8B8, like other olfactory receptors, plays a role in the detection of odorants and the initiation of olfactory signal transduction pathways, which ultimately leads to the perception of smell in the brain. Inhibition of OR8B8 can interrupt these signaling processes, providing a means to study the receptor's specific function within the broader olfactory system.
Chemically, OR8B8 inhibitors belong to diverse classes, ranging from small organic molecules to peptides or even larger synthetic compounds. These inhibitors are often identified through structure-based drug design approaches, which rely on understanding the three-dimensional conformation of the OR8B8 receptor and its binding sites. By leveraging this structural information, researchers can design compounds that fit precisely into these regions, blocking the receptor's ability to interact with its odorant ligands. Inhibitors of olfactory receptors like OR8B8 are useful for exploring the molecular dynamics of odor recognition, shedding light on the specific roles different receptors play in detecting and distinguishing between various odorants. These inhibitors help unravel the complexity of olfactory signaling, offering insights into how specific molecular interactions translate into sensory perceptions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may downregulate OR8B8 expression by binding to retinoic acid receptors, which can decrease transcription of genes within the olfactory receptor family. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG could reduce OR8B8 transcript levels by altering the methylation status of its gene promoter, thereby silencing its expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone might suppress OR8B8 expression via interaction with glucocorticoid receptors, leading to a restrained transcriptional activity of genes involved in olfactory signaling. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may decrease OR8B8 expression by inhibiting NF-kB signaling, which could lead to a reduction in the transcriptional activity of certain GPCR genes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could lead to the downregulation of OR8B8 by enhancing the activity of SIRT1, which might deacetylate histones associated with the OR8B8 gene promoter. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein might reduce the expression of OR8B8 by blocking tyrosine kinase activities that are upstream of transcription factors controlling GPCR gene expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate may inhibit OR8B8 expression by increasing histone acetylation levels, potentially leading to the repression of transcriptionally active regions near the OR8B8 gene. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Ketoconazole could decrease OR8B8 expression through the inhibition of cytochrome P450 enzymes, thereby altering the synthesis of steroid hormones that govern the expression of various olfactory receptors. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine might reduce OR8B8 expression by disrupting lysosomal function and autophagy, processes that can be crucial for the turnover and expression of membrane proteins including GPCRs. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 could suppress OR8B8 expression by selectively inhibiting MEK1/2, enzymes in the MAPK pathway, which are essential for the regulation of gene expression and cellular response to olfactory signals. | ||||||