OR7A10 Activators
OR7A10 can engage with the protein through various pathways that lead to its activation. Isoproterenol and forskolin, for instance, both facilitate the production of cAMP, a crucial secondary messenger in olfactory signal transduction. Isoproterenol achieves this by binding to beta-adrenergic receptors, which subsequently activate adenylate cyclase to increase cAMP levels. Forskolin, on the other hand, directly stimulates adenylate cyclase, bypassing receptor interaction and thus leading to a rise in cAMP. Elevated cAMP levels can enhance the functional activity of OR7A10, as it is part of the cascade that amplifies olfactory signals. Similarly, adenosine interacts with its own G protein-coupled receptors to boost adenylate cyclase activity and cAMP levels, which in turn may activate OR7A10. Histamine, through its action on H1 receptors, follows a slightly different pathway. It activates phospholipase C, leading to a cascade that produces diacylglycerol and inositol triphosphate (IP3). The release of IP3 results in increased intracellular calcium, another important messenger that could also contribute to the activation of OR7A10.
Nicotine, capsaicin, and menthol can modulate the membrane potential of sensory neurons, which is a critical factor in the activation of olfactory receptors like OR7A10. Nicotine activates nicotinic acetylcholine receptors, causing depolarization of olfactory sensory neurons that may lead to OR7A10 activation. Capsaicin and menthol target transient receptor potential (TRP) channels; capsaicin activates TRPV1, and menthol activates TRPM8 channels. Both actions result in neuronal depolarization, which can influence OR7A10 activity. Zinc ions, while not direct agonists, can stabilize the receptor conformation in a way that promotes OR7A10 activity. In addition to these modulatory substances, certain chemicals like citronellal, eugenol, limonene, and geraniol act as odorant molecules that directly bind to OR7A10. This binding is the primary mechanism for odor detection, and these chemicals are likely to activate OR7A10 by fitting into its binding site, triggering a conformational change that initiates the olfactory signal transduction process.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, a non-selective beta-adrenergic receptor agonist, activates beta-adrenergic receptors which can lead to the activation of adenylate cyclase. This in turn increases the production of cAMP, a secondary messenger that can enhance the functional activity of OR7A10 by promoting olfactory signal transduction, assuming OR7A10's involvement in this pathway. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine, through its action on H1 receptors, can activate phospholipase C, which results in the production of diacylglycerol and inositol triphosphate (IP3). IP3 can lead to an increase in intracellular calcium levels, which may promote OR7A10 activation as part of the olfactory transduction process. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates transient receptor potential vanilloid type 1 (TRPV1) channels, which may lead to depolarization in sensory neurons. This depolarization could affect the membrane potential and potentially activate OR7A10 if expressed in cells with TRPV1 influence. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
Menthol activates transient receptor potential melastatin 8 (TRPM8) channels, which may also lead to depolarization of sensory neurons. This depolarization could support the activation of OR7A10 by altering the neuronal membrane potential. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine interacts with its G protein-coupled receptors, which could lead to the activation of adenylate cyclase and result in increased cAMP. This increased cAMP may activate OR7A10 by enhancing the olfactory signal transduction pathway. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can act as allosteric modulators of various receptor activities. Although not a direct agonist, zinc could stabilize the active form of OR7A10, thus promoting its functional activation within its signaling pathway. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal, as a volatile terpenoid, may act as an odorant molecule for OR7A10, leading to its activation as part of the odor detection process in olfactory sensory neurons. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol, a phenylpropene, is also an odorant that could interact with OR7A10, leading to receptor activation and subsequent signal transduction in olfactory neurons. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene is a common scent compound that may specifically bind to and activate OR7A10 as part of its role in the detection of odorous compounds. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol, another terpenoid, could serve as a specific activating ligand for OR7A10, triggering the olfactory signal transduction cascade upon binding. | ||||||