OR6C70 Activators

Chemical activators of OR6C70 include a variety of compounds that initiate intracellular signaling cascades, leading to the functional activation of this protein. Forskolin, a well-known adenylyl cyclase activator, elevates intracellular levels of cAMP, a secondary messenger that activates protein kinase A (PKA). PKA, in turn, can activate OR6C70 by phosphorylating specific sites on the protein, leading to a conformational change that enhances its activity. Similarly, isoproterenol, a beta-adrenergic agonist, also raises cAMP levels, subsequently activating PKA, which then can phosphorylate and activate OR6C70. Adenosine, through its action on adenosine receptors, follows a similar path by increasing cAMP and activating PKA, which is known to phosphorylate various proteins, thereby including OR6C70 among those that can be activated by this kinase-mediated pathway.

Histamine and pilocarpine, by binding to their respective receptors, set off a series of events that elevate intracellular calcium levels or secondary messengers like cAMP. This increase in calcium can activate a range of calcium-dependent kinases capable of phosphorylating OR6C70, leading to its activation. Cinacalcet's activation of the calcium-sensing receptor (CaSR) also results in intracellular calcium increases that activate downstream kinases, which can then phosphorylate OR6C70. TRP channel activators such as capsaicin, icilin, and menthol alter calcium signaling within the cell, providing further opportunities for kinase-mediated activation of OR6C70. Lastly, vardenafil and sildenafil maintain elevated levels of cGMP by inhibiting phosphodiesterase type 5, which leads to the activation of protein kinase G (PKG). PKG can phosphorylate substrates including OR6C70, which would result in the activation of this protein through direct phosphorylation. These chemicals represent a variety of mechanisms by which OR6C70 can be activated through intracellular signaling pathways involving phosphorylation by different kinases.