OR6C65 Activators
Chemical activators of OR6C65 include a variety of compounds that engage different signaling pathways, leading to the activation of this protein. Forskolin, a diterpene, activates adenylyl cyclase, which catalyzes the conversion of ATP to cyclic AMP (cAMP). The elevated levels of cAMP can then activate protein kinase A (PKA). PKA is known to phosphorylate various proteins, and phosphorylation by PKA can activate OR6C65. Similarly, Isoproterenol, a synthetic catecholamine, acts as an agonist for beta-adrenergic receptors and also raises cAMP levels, resulting in PKA activation. This can promote the activation of OR6C65 through the same mechanism. In contrast, Capsaicin, a vanilloid compound, activates transient receptor potential vanilloid 1 (TRPV1) channels, which can initiate secondary messenger pathways, including calcium influx or other kinase pathways that lead to the activation of OR6C65 through phosphorylation by activated kinases.
Other activators work through modulation of G protein-coupled receptors (GPCRs) and ion channels. Zinc Gluconate can interact with GPCRs, potentially causing a conformational change in OR6C65, leading to its activation. Adenosine and Histamine bind to their respective receptors and initiate signaling cascades that can activate OR6C65 through GPCR pathway cross-talk. Pilocarpine, a muscarinic acetylcholine receptor agonist, increases intracellular calcium which can activate OR6C65 through calcium-dependent signaling pathways. Cinacalcet, an activator of the calcium-sensing receptor (CaSR), can also influence these pathways and lead to OR6C65 activation. Icilin and Menthol activate TRPM8 channels, altering calcium signaling, which can activate OR6C65. Lastly, Vardenafil and Sildenafil inhibit phosphodiesterase type 5, maintaining cGMP levels, which can activate kinases that phosphorylate and activate OR6C65, demonstrating the diversity of mechanisms by which chemical activators can regulate the activity of this protein through direct and indirect interactions within its signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylyl cyclase increasing cAMP levels, which can lead to the activation of PKA that can phosphorylate and thus activate OR6C65. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Agonist for beta-adrenergic receptors elevating cAMP and activating PKA, which in turn can phosphorylate and activate OR6C65. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Activates TRPV1 channels, initiating secondary messenger pathways that can lead to OR6C65 activation through phosphorylation by related kinases. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Can influence GPCR function, potentially interacting with OR6C65 directly or inducing a conformational change that leads to its activation. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Binds to adenosine receptors, initiating signaling cascades that can lead to OR6C65 activation through cross-talk with GPCR pathways. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Binds to histamine receptors, initiating signaling cascades that could result in the activation of OR6C65 through GPCR pathway interactions. | ||||||
Pilocarpine | 92-13-7 | sc-479256 | 100 mg | $250.00 | 1 | |
Muscarinic acetylcholine receptor agonist that increases intracellular calcium, possibly leading to the activation of OR6C65 through calcium signaling. | ||||||
Icilin | 36945-98-9 | sc-201557 sc-201557A | 10 mg 50 mg | $89.00 $252.00 | 9 | |
Agonist for TRPM8 channels, altering calcium signaling, which can result in OR6C65 activation through downstream effects on calcium-dependent pathways. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $38.00 $67.00 | ||
Activates TRPM8 channels, leading to changes in calcium signaling which can activate OR6C65 through subsequent signaling pathways. | ||||||
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $516.00 $720.00 $16326.00 | 7 | |
Inhibits phosphodiesterase type 5, sustaining cGMP levels, which can activate kinases that may phosphorylate and activate OR6C65. | ||||||