OR5D16 Activators
OR5D16 Activators are chemicals that either directly or indirectly enhance the functional activity of OR5D16, a G protein-coupled receptor (GPCR). These chemicals exert their effects by influencing the intracellular levels of calcium or cyclic AMP (cAMP), two crucial second messengers in cellular signaling. For example, capsaicin and ATP activate TRPV1 and purinergic receptors, respectively, which in turn increase intracellular calcium levels. This rise in calcium can enhance OR5D16 activity, as it is a GPCR that can be regulated by calcium levels. Additionally, dopamine, acetylcholine, nicotine, histamine, and serotonin can bind to their respective receptors, leading to an increase in intracellular calcium levels, which can also enhance OR5D16 activity.
In contrast, caffeine, rolipram, forskolin, ibudilast, and vinpocetine influence cAMP levels in cells. Caffeine inhibits phosphodiesterases, leading to increased cAMP levels. Rolipram, ibudilast, and vinpocetine inhibit specific phosphodiesterases, leading to a similar increasein cAMP levels. Forskolin directly stimulates adenylyl cyclase, an enzyme that catalyzes the conversion of ATP to cAMP. The increase in intracellular cAMP levels can enhance OR5D16 activity through the activation of protein kinase A (PKA). PKA can then phosphorylate OR5D16, a process that can enhance its functional activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates TRPV1, a non-selective cation channel. TRPV1 activation can increase intracellular calcium levels, which can enhance the functional activity of OR5D16, a G protein-coupled receptor that can be regulated by calcium levels. | ||||||
ADP | 58-64-0 | sc-507362 | 5 g | $54.00 | ||
ATP activates purinergic receptors, leading to increased intracellular calcium levels. The rise in calcium can enhance OR5D16 activity, as it is a G protein-coupled receptor regulated by calcium levels. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits phosphodiesterases, leading to increased cAMP levels. Increased cAMP can enhance OR5D16 activity through the activation of protein kinase A, which can phosphorylate G protein-coupled receptors like OR5D16. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase-4, leading to increased cAMP levels. Increased cAMP can enhance OR5D16 activity through the activation of protein kinase A, which can phosphorylate G protein-coupled receptors like OR5D16. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to increased cAMP levels. Increased cAMP can enhance OR5D16 activity through activation of protein kinase A, which can phosphorylate G protein-coupled receptors like OR5D16. | ||||||
Ibudilast | 50847-11-5 | sc-203080 | 10 mg | $218.00 | 1 | |
Ibudilast inhibits phosphodiesterase-3 and -4, leading to increased cAMP levels. Increased cAMP can enhance OR5D16 activity through activation of protein kinase A, which can phosphorylate G protein-coupled receptors like OR5D16. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine inhibits phosphodiesterase-1, leading to increased cAMP levels. Increased cAMP can enhance OR5D16 activity through activation of protein kinase A, which can phosphorylate G protein-coupled receptors like OR5D16. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can bind to and activate dopamine receptors, leading to increased intracellular calcium levels. The rise in calcium can enhance OR5D16 activity, as it is a G protein-coupled receptor regulated by calcium levels. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine can bind to and activate histamine receptors, leading to increased intracellular calcium levels. The rise in calcium can enhance OR5D16 activity, as it is a G protein-coupled receptor regulated by calcium levels. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $530.00 | 3 | |
Serotonin can bind to and activate serotonin receptors, leading to increased intracellular calcium levels. The rise in calcium can enhance OR5D16 activity, as it is a G protein-coupled receptor regulated by calcium levels. | ||||||