OR5AS1 Activators
OR5AS1 act through various mechanisms to increase intracellular cyclic AMP (cAMP), which can enhance the activity of this olfactory receptor. Isoproterenol, a beta-adrenergic agonist, stimulates beta-adrenergic receptors, leading to the activation of adenylyl cyclase and an increase in cAMP. Similarly, epinephrine and norepinephrine, both of which bind to beta-adrenergic receptors, can raise cAMP levels and thus, can activate OR5AS1. Forskolin serves as a direct stimulator of adenylyl cyclase, thereby boosting cAMP levels and activating OR5AS1. Dopamine can also elevate cAMP by interacting with dopamine receptors that activate Gs proteins, which in turn stimulate adenylyl cyclase. Histamine binds to H2 receptors, and adenosine interacts with A2A and A2B receptors, with both pathways leading to increased cAMP levels and activation of OR5AS1.
Prostaglandin E2 (PGE2) interacts with EP2 and EP4 receptors coupled to Gs proteins, which can amplify cAMP concentrations and activate OR5AS1. IBMX, a non-specific inhibitor of phosphodiesterases, prevents the degradation of cAMP, sustaining its activity and thus, can activate OR5AS1. Vardenafil and sildenafil, primarily known as PDE5 inhibitors, can also increase cAMP levels due to their cross-reactivity with PDEs that degrade cAMP. This rise in cAMP can lead to the activation of OR5AS1. Lastly, rolipram selectively inhibits PDE4, which is responsible for cAMP breakdown. By inhibiting PDE4, rolipram can result in elevated cAMP levels that can activate OR5AS1, completing the array of mechanisms through which these chemical activators enhance OR5AS1 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that activates the beta-adrenergic receptors. OR5AS1, as an olfactory receptor, can be influenced by intracellular levels of cyclic AMP (cAMP), which are increased upon activation of these receptors by isoproterenol, leading to a possible enhancement of OR5AS1 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX, or 3-isobutyl-1-methylxanthine, is a non-specific inhibitor of phosphodiesterases, which degrade cAMP. By preventing cAMP degradation, IBMX can sustain or elevate the activity of cAMP-dependent pathways, potentially leading to the activation of OR5AS1 through enhanced PKA phosphorylation of proteins related to olfactory signaling. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, also known as adrenaline, interacts with beta-adrenergic receptors to increase intracellular cAMP levels. This rise in cAMP can activate PKA, which could then phosphorylate components of the signaling pathway associated with OR5AS1, thereby activating the receptor. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Norepinephrine, similar to epinephrine, binds to beta-adrenergic receptors and can lead to an increase in intracellular cAMP levels, potentially resulting in the activation of OR5AS1 via cAMP-dependent signaling mechanisms. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can bind to and activate dopamine receptors that are coupled to Gs proteins, which in turn can stimulate adenylyl cyclase to increase cAMP levels. Through this pathway, dopamine may contribute to the activation of OR5AS1. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine can bind to H2 receptors which are positively coupled to adenylyl cyclase via Gs proteins, leading to an increase in cAMP. This elevation in cAMP could activate PKA and consequently may activate OR5AS1 by promoting phosphorylation cascades within olfactory signal transduction pathways. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine interacts with A2A and A2B receptors which are coupled to Gs proteins, leading to an increase in cAMP levels. Elevated cAMP can activate PKA, which may play a role in the activation of OR5AS1 by phosphorylating proteins involved in olfactory signal transduction. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) acts through EP2 and EP4 receptors which are Gs protein-coupled receptors that stimulate adenylyl cyclase, leading to increased cAMP levels. This elevation of cAMP could activate the PKA signaling pathway, potentially resulting in activation of OR5AS1. | ||||||
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $526.00 $735.00 $16653.00 | 7 | |
Vardenafil is a selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5) which can lead to elevated cGMP levels. Though it primarily affects cGMP, cross-reactivity with PDEs that degrade cAMP can result in increased cAMP levels that activate PKA and could thereby activate OR5AS1. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which is responsible for breaking down cAMP. By inhibiting PDE4, rolipram can raise cAMP levels, potentially leading to activation of PKA and subsequent activation of OR5AS1 through enhanced phosphorylation events in the olfactory signaling pathway. | ||||||