OR4K2 Activators
OR4K2 activation is intricately linked to the intracellular levels of cyclic AMP (cAMP), a second messenger crucial for the transmission of cellular signals. Certain activators increase cAMP production by directly stimulating enzymes like adenylyl cyclase, which catalyzes the conversion of ATP to cAMP, thus fostering an environment conducive to the activation of OR4K2. In parallel, other agents target different phosphodiesterase (PDE) enzymes, which are tasked with cAMP degradation. By inhibiting these PDEs, these activators effectively boost cAMP levels, indirectly promoting OR4K2 activation. The delicate balance of cAMP synthesis and degradation is thus a critical factor in the regulation of OR4K2 activity, and the availability of high cAMP levels serves as a pivotal step in its activation pathway.
The nuanced control of OR4K2 extends beyond the simple elevation of cAMP, as specific PDE inhibitors selectively increase cAMP concentrations in certain cellular compartments, directly influencing OR4K2 activation. The action of these inhibitors is not uniform; rather, they exhibit selectivity towards different PDE isoenzymes, allowing for a finely tuned modulation of the signaling milieu. Additionally, some activators are structurally optimized derivatives of endogenous compounds, offering enhanced solubility and potency in augmenting cAMP levels within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to increased production of cyclic AMP (cAMP), a second messenger involved in the signaling of many receptors, including OR4K2. Elevated cAMP levels enhance the activation of OR4K2. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, enzymes that break down cAMP. By preventing cAMP degradation, IBMX indirectly sustains higher cAMP levels, which supports the activation of OR4K2. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine, while known for its antagonistic effects on adenosine receptors, also inhibits phosphodiesterase, leading to increased intracellular cAMP levels, which can enhance the activation of OR4K2. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Theophylline inhibits phosphodiesterase, thus increasing cAMP levels in cells. Elevated cAMP is crucial for the activation of OR4K2 through the cAMP-dependent pathway. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a synthetic catecholamine that activates adenylyl cyclase via beta-adrenergic receptors, resulting in increased cAMP production. This rise in cAMP levels can lead to the activation of OR4K2. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram selectively inhibits phosphodiesterase-4, which degrades cAMP. By maintaining cAMP at a high level, rolipram indirectly enhances the activation of OR4K2. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast inhibits phosphodiesterase-5, leading to increased cAMP levels, which are involved in OR4K2 activation. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $147.00 | ||
Anagrelide inhibits phosphodiesterase-3, resulting in increased cAMP levels. The higher concentration of cAMP facilitates the activation of OR4K2. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin has been shown to inhibit phosphodiesterase activity, which would prevent the degradation of cAMP, leading to its accumulation. Higher cAMP levels can result in the activation of OR4K2. | ||||||
NKH 477 | 138605-00-2 | sc-204130 sc-204130A | 5 mg 50 mg | $219.00 $904.00 | 1 | |
NKH 477 is a water-soluble forskolin derivative that activates adenylyl cyclase, thus increasing intracellular cAMP levels. Elevated cAMP is known to activate OR4K2. | ||||||