OR1I1 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $100.00 | 6 | |
Glucocorticoid receptor agonist that translocates to the nucleus and downregulates the expression of many genes, including some GPCRs. If OR1I1 expression is regulated by glucocorticoid-responsive elements, hydrocortisone can lead to decreased OR1I1 expression and function. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Non-selective beta-adrenergic receptor antagonist that can decrease cyclic AMP levels, which in turn may reduce the activity of protein kinase A (PKA). Since PKA can phosphorylate and regulate GPCRs, propranolol may lead to reduced phosphorylation and inhibition of OR1I1. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
Inactivates Gi/o proteins by ADP-ribosylation, potentially reducing the inhibitory regulation of adenylate cyclase. If OR1I1 signaling involves Gi/o-mediated pathways, pertussis toxin can lead to its functional inhibition. | ||||||
Clozapine | 5786-21-0 | sc-200402 sc-200402A | 50 mg 500 mg | $68.00 $357.00 | 11 | |
Antipsychotic that binds to numerous neurotransmitter receptors, including some GPCRs, and can decrease cAMP levels indirectly. This action may lead to the inhibition of OR1I1 if it is coupled to cAMP pathways. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
P2 purinergic receptor antagonist that can block ATP-induced signaling. If OR1I1 interacts with purinergic signaling, suramin can inhibit its function. | ||||||
Mibefradil dihydrochloride | 116666-63-8 | sc-204083 sc-204083A | 10 mg 50 mg | $209.00 $848.00 | 4 | |
T-type calcium channel blocker that reduces calcium influx, potentially affecting calcium-dependent signaling pathways. If OR1I1 signaling is calcium-dependent, mibefradil can inhibit OR1I1 activity. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $127.00 | 18 | |
Angiotensin II receptor type 1 antagonist that can inhibit Gq protein signaling, potentially affecting GPCR function. If OR1I1 is regulated by Gq-mediated pathways, losartan can inhibit OR1I1 activity. | ||||||