Date published: 2025-12-24

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OR1D2 Inhibitors

OR1D2 inhibitor compounds like Zinc Gluconate and Copper Sulfate can interact directly with the olfactory receptor, leading to structural modifications that prevent the receptor from binding to its specific odorant ligands. This interaction can result in the inactivation of the receptor's ability to initiate a signal upon ligand binding. Molecules such as Caffeine and Chloroquine act on broader signaling cascades that are pivotal for olfactory receptor function, such as those mediated by G-protein-coupled receptors and cyclic AMP. By altering these pathways, the compounds can modulate the receptor's ability to propagate a signal even after ligand interaction. Furthermore, Methimazole and Iodoacetamide target the functional groups of amino acids within protein structures. By modifying sulfhydryl groups, specifically those of cysteines, these compounds can affect the conformation and hence the activity of OR1D2. Similarly, Amiloride and Lidocaine impact ion channels and neuronal excitability, thereby indirectly affecting the signaling potential of olfactory receptors.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Zinc

7440-66-6sc-213177
100 g
$47.00
(0)

Zinc ions can bind to olfactory receptor sites, potentially causing conformational changes that prevent ligand binding to OR1D2.

Copper(II) sulfate

7758-98-7sc-211133
sc-211133A
sc-211133B
100 g
500 g
1 kg
$45.00
$120.00
$185.00
3
(1)

Copper can interact with thiol groups in proteins, possibly leading to the inhibition of olfactory receptor function by altering the receptor conformation.

Quinine hydrochloride dihydrate

6119-47-7sc-212619
sc-212619A
5 g
25 g
$63.00
$210.00
(0)

Known as a bitter compound, quinine can interact with G-protein-coupled receptors, potentially altering G-protein signaling cascades that include OR1D2.

Caffeine

58-08-2sc-202514
sc-202514A
sc-202514B
sc-202514C
sc-202514D
50 g
100 g
250 g
1 kg
5 kg
$32.00
$66.00
$95.00
$188.00
$760.00
13
(1)

As an adenosine receptor antagonist, caffeine can influence cyclic AMP levels, potentially affecting OR1D2 signal transduction, which relies on cAMP as a secondary messenger.

Methimazole

60-56-0sc-205747
sc-205747A
10 g
25 g
$69.00
$110.00
4
(0)

Methimazole is known to modify sulfhydryl groups, and can alter the activity of proteins with critical cysteine residues, possibly affecting OR1D2 function.

Lidocaine

137-58-6sc-204056
sc-204056A
50 mg
1 g
$50.00
$128.00
(0)

As a local anesthetic, lidocaine can cause temporary loss of sensation, potentially inhibiting signal transduction in olfactory receptors like OR1D2.

Capsaicin

404-86-4sc-3577
sc-3577C
sc-3577D
sc-3577A
50 mg
250 mg
500 mg
1 g
$94.00
$173.00
$255.00
$423.00
26
(1)

Capsaicin activates TRPV1, a non-selective cation channel, potentially influencing cellular signaling pathways that intersect with those of OR1D2.

(±)-Menthol

89-78-1sc-250299
sc-250299A
100 g
250 g
$38.00
$67.00
(0)

Menthol is known to modulate ion channels, potentially influencing the function of OR1D2 by altering the ion channel environment of olfactory neurons.

α-Iodoacetamide

144-48-9sc-203320
25 g
$250.00
1
(1)

Iodoacetamide alkylates cysteine residues, which can disrupt protein function by covalently modifying cysteine-containing olfactory receptors like OR1D2.

Amiloride • HCl

2016-88-8sc-3578
sc-3578A
25 mg
100 mg
$22.00
$56.00
6
(2)

Known to inhibit epithelial sodium channels, amiloride can indirectly influence the signaling environment of olfactory receptors such as OR1D2.