OR10S1 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $66.00 $280.00 $1300.00 | 11 | |
Picrotoxin acts as a noncompetitive antagonist at GABA_A receptor chloride channels. By inhibiting these channels, it reduces inhibitory neurotransmission, which could indirectly downregulate OR10S1 by increasing neural excitability and thereby potentially altering OR10S1 receptor activity or expression in olfactory neurons. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 inhibits Protein Kinase C (PKC) isoforms, which are downstream effectors in the GPCR signaling pathway. OR10S1, being a GPCR, may signal through PKC-modulated pathways, and therefore, its activity could be indirectly diminished by Gö 6983 through reduced PKC-mediated phosphorylation events. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $93.00 $356.00 | 13 | |
SQ22536 inhibits adenylyl cyclase, reducing the conversion of ATP to cAMP. As OR10S1 may couple to Gs proteins to increase intracellular cAMP levels, inhibition of adenylyl cyclase by SQ22536 could lead to decreased OR10S1 signaling due to lower cAMP-mediated activation of downstream targets. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
Pertussis toxin ADP-ribosylates and inactivates Gi/o-type G proteins, which could be coupled to OR10S1. Inactivation of Gi/o proteins would block OR10S1-mediated inhibition of adenylyl cyclase, leading to reduced signaling through this inhibitory pathway. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine blocks L-type calcium channels, potentially attenuating calcium influx. Since OR10S1 may modulate intracellular signaling cascades that depend on calcium signaling, blocking these channels could indirectly reduce OR10S1 activity due to altered calcium homeostasis. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 inhibits Rho-associated protein kinase, involved in actin cytoskeleton organization. As GPCR signaling, including OR10S1's, can involve cytoskeletal changes, Y-27632 could impair OR10S1's ability to transduce signals by destabilizing cytoskeletal dynamics. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB inhibits IP_3 receptors, reducing calcium release from intracellular stores. As OR10S1 signaling might be influenced by intracellular calcium levels, 2-APB could decrease OR10S1 activity by limiting calcium-dependent signaling events. | ||||||
NF 023 | 104869-31-0 | sc-204124 sc-204124A | 10 mg 50 mg | $158.00 $617.00 | 1 | |
NF023 selectively antagonizes the alpha subunits of Gi/o proteins, thereby inhibiting their activity. This would prevent OR10S1 from signaling through Gi/o protein-dependent pathways, leading to decreased OR10S1 activity. | ||||||