OR10H4 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin binds to and activates the TRPV1 receptor, which can lead to an influx of calcium ions. This increased intracellular calcium can desensitize GPCRs like OR10H4 by promoting their phosphorylation and internalization, thereby inhibiting their signaling. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine interferes with dopaminergic signaling and alters membrane phospholipid metabolism. By disrupting membrane dynamics, it can inhibit GPCR function including OR10H4 by affecting its proper localization and signaling efficacy. | ||||||
Haloperidol | 52-86-8 | sc-507512 | 5 g | $190.00 | ||
As a dopamine receptor antagonist, haloperidol can also impact GPCR signaling. It may indirectly inhibit OR10H4 activity by altering G-protein coupling and downstream signaling cascades that OR10H4 relies on. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
Pertussis toxin permanently disables Gi/o proteins by ADP-ribosylation. Since OR10H4 signaling relies on Gi/o proteins to mediate inhibition of adenylate cyclase, pertussis toxin can indirectly inhibit OR10H4 signaling. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol, a beta-adrenergic receptor antagonist, can impact cAMP levels in cells. By doing so, it may indirectly inhibit OR10H4 by altering the balance of intracellular signaling pathways that control OR10H4 activity. | ||||||
Rimonabant | 168273-06-1 | sc-205491 sc-205491A | 5 mg 10 mg | $72.00 $160.00 | 15 | |
Rimonabant is a CB1 cannabinoid receptor antagonist that can influence GPCR signaling. It may indirectly inhibit OR10H4 by modulating the downstream signaling pathways that are shared with cannabinoid receptors. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor that can reduce levels of PIP3, indirectly leading to a decrease in OR10H4 activity, as PIP3 is involved in the signaling pathways that regulate GPCR function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor that similarly to wortmannin, can decrease PIP3 levels and indirectly inhibit OR10H4 signaling. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
High concentrations of zinc can inhibit GPCR signaling by altering receptor conformation or interacting with receptor-associated proteins. This can lead to the indirect inhibition of OR10H4. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Suramin is a GPCR antagonist that can inhibit G-protein activation by preventing receptor-G-protein interaction. This can indirectly lead to the inhibition of OR10H4 signaling. | ||||||