Olfr936 Inhibitors
Olfr936, an olfactory receptor, plays a crucial role in the intricate process of olfactory signal transduction. Belonging to the G-protein-coupled receptor (GPCR) family, Olfr936, like other olfactory receptors, possesses a 7-transmembrane domain structure and is integral to the recognition and transduction of odorant signals. The olfactory receptor gene family, including Olfr936, constitutes the largest in the genome, emphasizing its significance in mediating our perception of smell. Inhibition of Olfr936 involves a spectrum of mechanisms, either directly targeting the receptor or influencing associated pathways. Atropine, for instance, directly inhibits the cholinergic signaling pathway by blocking acetylcholine receptors, potentially disrupting neural transmission essential for olfactory signal transduction. Pertussis Toxin interferes with G protein signaling pathways, disrupting GPCR-mediated transduction of odorant signals and attenuating Olfr936-induced neuronal responses. Tetrodotoxin, a sodium channel blocker, directly inhibits neuronal signaling by blocking sodium channels, disrupting the transmission of signals initiated by Olfr936 activation.
Moreover, chemical inhibitors such as 2-APB, a modulator of intracellular calcium signaling, and AC5/6 Inhibitor, affecting cAMP signaling, showcase the intricacies of olfactory transduction pathways. Each inhibitor exerts its influence on specific biochemical or cellular pathways, ultimately impacting Olfr936 function and the broader olfactory system. These mechanisms underscore the complexity of olfactory signal processing and provide avenues for a nuanced understanding of how chemical modulation can shape our perception of smell.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Atropine | 51-55-8 | sc-252392 | 5 g | $200.00 | 2 | |
Atropine, an acetylcholine receptor antagonist, directly inhibits the cholinergic signaling pathway. By blocking acetylcholine receptors, it interferes with the neural transmission necessary for olfactory signal transduction, potentially inhibiting Olfr936-mediated responses to odorants. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Sulfate, an inhibitor of metalloproteases, directly influences metalloprotease activity. Inhibition of metalloproteases may indirectly impact Olfr936, as these enzymes can modulate the extracellular matrix and affect the olfactory receptor environment, potentially disrupting odorant recognition. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
Pertussis Toxin, a G protein inhibitor, directly interferes with G protein signaling pathways. By inhibiting G protein function, it disrupts the GPCR-mediated transduction of odorant signals, potentially attenuating Olfr936-induced neuronal responses to odorants. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB, an IP3 receptor inhibitor, directly influences intracellular calcium signaling. Inhibition of IP3 receptors may indirectly impact Olfr936, as calcium signaling is integral to olfactory transduction, potentially modulating the sensitivity of olfactory neurons to Olfr936 activation by odorants. | ||||||
Captopril | 62571-86-2 | sc-200566 sc-200566A | 1 g 5 g | $48.00 $89.00 | 21 | |
Captopril, an ACE inhibitor, directly interferes with angiotensin-converting enzyme (ACE) activity. Inhibition of ACE may indirectly impact Olfr936, as the renin-angiotensin system is implicated in olfactory function, potentially affecting the modulation of olfactory responses to various odorants. | ||||||
Tetrandrine | 518-34-3 | sc-201492 sc-201492A | 100 mg 250 mg | $55.00 $98.00 | 9 | |
Tetrandrine, a calcium channel blocker, directly inhibits calcium channels crucial for neuronal signaling. By blocking calcium channels, it interferes with the generation of action potentials in olfactory neurons, potentially disrupting the transmission of signals initiated by Olfr936 activation. | ||||||
CGP 37157 | 75450-34-9 | sc-202097 sc-202097A | 5 mg 25 mg | $113.00 $454.00 | 3 | |
CGP-37157, a mitochondrial calcium uniporter inhibitor, directly influences mitochondrial calcium uptake. Inhibition of mitochondrial calcium uniporter may indirectly impact Olfr936, as mitochondrial calcium signaling is implicated in olfactory transduction, potentially modulating the responsiveness of olfactory neurons to Olfr936 activation by odorants. | ||||||