Olfr898 Inhibitors
Olfr898, a member of the olfactory receptor family in Mus musculus (house mouse), holds a pivotal role in the intricate process of olfaction. These olfactory receptors, including Olfr898, belong to the G-protein-coupled receptor (GPCR) superfamily, characterized by a 7-transmembrane domain structure. Olfr898 functions as a molecular sensor for detecting odorant molecules in the nasal environment, initiating a complex signaling cascade that ultimately leads to the perception of specific odors.
Inhibition of Olfr898 occurs through the modulation of key components within the olfactory signaling pathway. While direct inhibitors specifically binding to Olfr898 may be limited, indirect inhibition is achieved by targeting elements of the pathway. Various chemical compounds can influence Olfr898 function by acting on critical components such as adenylyl cyclase, kinases like PKA and PKC, calcium channels, MAPK pathways, and GPCR signaling. These compounds indirectly disrupt olfactory receptor signaling, potentially leading to the down-regulation of Olfr898 function and affecting the perception of specific odors in house mice. The intricate interplay of these inhibitors with the complex signaling networks associated with olfaction highlights the dynamic nature of olfactory perception and the potential for precise modulation of Olfr898 and related receptors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a phosphodiesterase (PDE4) inhibitor that indirectly influences Olfr898 by elevating intracellular cAMP levels. This leads to the activation of protein kinase A (PKA) and can impact olfactory receptor signaling pathways, potentially down-regulating Olfr898 function and affecting odor perception. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker that can indirectly inhibit Olfr898 by reducing calcium influx. This disruption of calcium signaling may lead to the down-regulation of olfactory receptor function and affect the perception of specific odors. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of MEK1, which indirectly influences the MAPK pathway. By targeting this pathway, it may affect Olfr898 indirectly, as MAPK signaling has connections with olfactory receptor signaling, potentially leading to changes in receptor function and odor perception. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $95.00 $363.00 | 13 | |
SQ 22536 is an adenylate cyclase inhibitor, indirectly influencing Olfr898 by reducing cAMP production. Inhibition of adenylate cyclase can lead to down-regulation of Olfr898-mediated signal transduction and odor perception. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $136.00 | 20 | |
KN-62 is a potent inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). Its indirect impact on Olfr898 may occur by inhibiting CaMKII, potentially influencing olfactory receptor signaling and the receptor's response to specific odors. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis Toxin is known to inhibit G-protein signaling, including the type of G proteins involved in olfactory receptor signaling. By blocking G protein activity, it may indirectly down-regulate Olfr898 function and affect the perception of specific odors. | ||||||
Phytic acid solution | 83-86-3 | sc-205806 sc-205806A | 100 ml 500 ml | $151.00 $515.00 | ||
Phytic acid solution is a naturally occurring molecule that can influence cellular signaling, including pathways related to olfactory receptors. Its effects on intracellular signaling may indirectly affect Olfr898 function and odor perception by interfering with specific signaling events. | ||||||
Gallein | 2103-64-2 | sc-202631 | 50 mg | $85.00 | 20 | |
Gallein is a G protein-coupled receptor (GPCR) inhibitor that can indirectly modulate olfactory receptor signaling by affecting GPCR function. By interfering with GPCR signaling pathways, it may have an impact on Olfr898 and odor perception by disrupting downstream events in the receptor's signaling cascade. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a β-adrenergic receptor agonist that indirectly influences Olfr898 via adenylyl cyclase activation and increased cAMP levels. This can enhance olfactory receptor signaling pathways, potentially amplifying receptor function and affecting odor perception. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a selective PKC inhibitor that indirectly down-regulates olfactory receptor signaling by inhibiting PKC activity. This action disrupts PKC-mediated pathways, potentially impacting Olfr898 function and the perception of specific odors. | ||||||