Olfr724 Inhibitors
Olfr724, a member of the olfactory receptor family, is essential for the perception of smells in Mus musculus (house mouse). It belongs to the vast family of G-protein-coupled receptors (GPCRs) that play a pivotal role in recognizing odorant molecules and initiating neuronal responses. These receptors, including Olfr724, share a common 7-transmembrane domain structure, resembling other receptors involved in neurotransmission and hormonal signaling.
The function of Olfr724 lies in the recognition and G protein-mediated transduction of odorant signals. It is a key component of the olfactory system, responsible for initiating the perception of smells. Inhibition of Olfr724 can be achieved through both direct and indirect means using various chemicals. Direct inhibitors specifically target Olfr724, preventing odorant binding and disrupting the initiation of neuronal responses responsible for smell perception. Indirect inhibitors, on the other hand, modulate the GPCR signaling pathway, calcium channels, oxidative stress pathways, neurotransmitter signaling, and other related processes, ultimately impairing Olfr724's functionality in perceiving odorants. In summary, Olfr724 is a crucial player in the olfactory system, facilitating the recognition and transduction of odorant signals. Inhibition of this receptor can be achieved through various chemicals, each with its specific mechanism of action. These inhibitors shed light on the intricate processes underlying olfactory perception in house mice, offering valuable insights into the functioning of the olfactory system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
Pertussis Toxin (PTX) is an indirect inhibitor that interferes with the GPCR signaling pathway. PTX modifies G-proteins, disrupting downstream signaling from Olfr724, ultimately impairing the perception of odorants. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF 96365 is an indirect inhibitor that disrupts the shared 7-transmembrane domain structure of GPCRs, including Olfr724. It impairs the receptor's structural integrity, leading to compromised odorant recognition and inhibited G protein-mediated signaling. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is an indirect inhibitor that acts as a calcium channel blocker, influencing calcium influx and affecting the downstream signaling cascade of Olfr724. This leads to reduced functionality in perceiving odorants. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is an indirect inhibitor that influences the calcineurin-NFAT signaling pathway. By inhibiting calcineurin, it indirectly affects Olfr724's function, reducing the perception of odors. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetylcysteine is an indirect inhibitor that modulates oxidative stress pathways. It reduces oxidative stress, which can influence the neuronal response to odorants mediated by Olfr724. | ||||||
Scopolamine | 51-34-3 | sc-473216 sc-473216A sc-473216B | 100 mg 500 mg 1 g | $169.00 $496.00 $771.00 | 2 | |
Scopolamine is an indirect inhibitor that targets muscarinic acetylcholine receptors, affecting neurotransmitter signaling and potentially altering neuronal responses to odorants through cross-talk with Olfr724. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
Lidocaine is an indirect inhibitor that blocks sodium channels, influencing neuronal excitability and potentially modulating Olfr724's responses to odorants. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol is an indirect inhibitor that acts on adrenergic receptors, potentially influencing the sympathetic nervous system's impact on olfactory perception and Olfr724's responses to odorants. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an indirect inhibitor that affects calcium signaling in neurons, modulating intracellular calcium levels and indirectly influencing Olfr724's function in transducing odorant signals by altering calcium-dependent processes in olfactory neurons. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an indirect inhibitor that activates adenylyl cyclase, affecting cAMP levels in olfactory neurons. By modulating cAMP, it can indirectly influence Olfr724's function, altering the neuronal response to odorants and olfactory perception. | ||||||