Olfr698 Inhibitors
Olfr698, also known as Olfactory Receptor Family 2 Subfamily AG Member 16, plays a pivotal role in the sensory perception of odors in Mus musculus (house mouse). It belongs to the family of olfactory receptors, which are essential components of the olfactory system, facilitating the detection and initial processing of odorant molecules in the nasal passages. These olfactory receptors are categorized as G-protein-coupled receptors (GPCRs), characterized by their 7-transmembrane domain structure, shared with other neurotransmitter and hormone receptors. Olfr698, like its counterparts, is responsible for recognizing odorants and initiating signaling cascades mediated by G proteins, ultimately leading to the perception of smell. The olfactory receptor gene family is notably the largest in the genome, and the nomenclature assigned to these genes and proteins in Mus musculus is unique to this organism.
Inhibiting Olfr698 presents a challenge due to its role in signal transduction rather than conventional enzymatic or structural functions. Consequently, the chemical inhibition of Olfr698 typically involves indirect mechanisms that target the intricate intracellular signaling pathways associated with olfaction. A variety of chemicals, including those modulating cAMP, MEK/ERK, JNK, JAK kinases, AKT, Wnt, NF-κB, and GPCR desensitization pathways, can indirectly influence Olfr698. These chemicals exert their effects by disrupting downstream events required for proper olfactory receptor gene expression and function. In conclusion, Olfr698 is a crucial player in the house mouse's ability to detect and discriminate odors, contributing to their sensory perception. Inhibiting Olfr698 involves the modulation of complex signaling pathways related to olfaction. While direct chemical inhibitors may be elusive, understanding the potential indirect inhibitors and their effects on olfactory pathways enhances our knowledge of sensory biology. Further research and experimental validation are necessary to elucidate the precise mechanisms of Olfr698 inhibition and their implications in the field of olfaction.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective phosphodiesterase 4 (PDE4) inhibitor, indirectly impacting Olfr698 by elevating intracellular cAMP levels in olfactory neurons. Increased cAMP enhances olfactory signal transduction, thereby influencing Olfr698 activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a MEK/ERK pathway inhibitor, indirectly affecting Olfr698. By blocking this pathway, it disrupts the downstream signaling events that regulate olfactory receptor gene expression, leading to inhibition of Olfr698. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a specific JNK inhibitor, indirectly affecting Olfr698 by interfering with the JNK signaling pathway involved in olfactory signal transduction. Inhibition of JNK disrupts the downstream events crucial for olfactory receptor function. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
Ruxolitinib inhibits JAK kinases, indirectly influencing Olfr698 expression by disrupting downstream events essential for proper olfactory receptor function. JAK kinases are involved in olfactory receptor signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3-kinase inhibitor that impacts the AKT pathway in olfactory neurons. By inhibiting this pathway, it indirectly affects Olfr698 expression, as the AKT pathway regulates downstream events related to olfactory receptor gene expression. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
XAV939 is a tankyrase inhibitor that modulates the Wnt pathway, indirectly affecting Olfr698. By disrupting the Wnt pathway, it interferes with cellular processes necessary for proper olfactory receptor function and gene expression. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 is an NF-κB inhibitor, indirectly suppressing Olfr698. NF-κB is involved in regulating olfactory receptor function and gene expression, and its inhibition disrupts these processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3-kinase inhibitor that impacts the PLC-IP3 pathway in olfactory neurons. By inhibiting this pathway, it indirectly influences Olfr698 by disrupting the intracellular signaling processes required for proper olfactory receptor function. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42 is a JAK2 inhibitor, indirectly influencing Olfr698 expression by disrupting downstream events essential for proper olfactory receptor function. JAK2 kinases are involved in olfactory receptor signaling pathways. | ||||||
Compound 101 | 161125-36-6 | sc-507528 | 5 mg | $108.00 | ||
This chemical acts as a G protein-coupled receptor kinase 3 (GRK3) inhibitor, promoting GPCR desensitization in olfactory neurons. By enhancing GPCR desensitization, it indirectly inhibits Olfr698 and reduces the responsiveness of olfactory receptors, including Olfr698. | ||||||