Olfr659 Inhibitors
Olfr659, a member of the olfactory receptor family, stands as a key player in the intricate process of olfaction. Positioned on the surface of olfactory sensory neurons, Olfr659 functions as a G protein-coupled receptor (GPCR), specializing in the detection and transduction of odorant signals. This receptor, like its counterparts, is integral to the initial steps of odor perception, binding to specific odorant molecules and triggering a cascade of events that culminate in the generation of neural signals perceived as distinct smells. With its refined specificity for diverse odorants, Olfr659 contributes significantly to the sensory experience, exemplifying the intricacy and precision inherent in the olfactory system.
Inhibition of Olfr659 involves the strategic targeting of key cellular pathways crucial for its normal functioning. Chemical inhibitors act on specific signaling cascades associated with Olfr659 activity, indirectly influencing its function. For instance, inhibition of the PI3K/Akt pathway disrupts downstream components essential for proper olfactory receptor functioning, impacting Olfr659 indirectly. Similarly, interference with the MAPK/ERK pathway alters downstream elements crucial for normal olfactory receptor activity, leading to indirect inhibition of Olfr659. Additionally, inhibitors acting on TGF-β signaling pathways can indirectly affect Olfr659, emphasizing the intricate network of cellular processes that contribute to olfactory receptor regulation. The modulation of these pathways, orchestrated by various chemical inhibitors, unveils the regulatory mechanisms governing Olfr659, providing insights into the complex interplay within olfactory sensory neurons and potential avenues for influencing receptor dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a kinase in the mTOR pathway. Its modulation of this pathway indirectly influences Olfr659 by altering downstream components essential for proper olfactory receptor activity and signaling cascades. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB-203580 inhibits p38 MAPK, a kinase involved in various cellular processes. Its interference with the MAPK pathway indirectly impacts Olfr659, disrupting the downstream signaling required for normal olfactory receptor activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits PI3K, a key enzyme in the PI3K/Akt pathway. By disrupting this pathway, the chemical indirectly affects Olfr659, as Akt modulation influences downstream components essential for proper olfactory receptor functioning. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a MEK1/2 inhibitor disrupting the MAPK/ERK pathway. Its interference with this pathway indirectly impacts Olfr659, as downstream components crucial for normal olfactory receptor activity are modulated, leading to receptor inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin acts as a PI3K inhibitor, disrupting the PI3K/Akt pathway. This interference influences olfactory signaling cascades, leading to indirect inhibition of Olfr659 by modulating crucial components downstream of the receptor. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK1 inhibitor disrupting the MAPK/ERK pathway. Its interference with this pathway indirectly impacts Olfr659, as downstream components crucial for normal olfactory receptor activity are modulated, leading to receptor inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor disrupting the JNK pathway. Its impact on this pathway indirectly influences Olfr659 by altering downstream components crucial for normal olfactory receptor activity and signaling cascades. | ||||||
AZD5363 | 1143532-39-1 | sc-503190 | 5 mg | $309.00 | ||
AZD5363 is an Akt inhibitor disrupting the PI3K/Akt pathway. By targeting this key signaling cascade, the chemical indirectly hampers Olfr659 function, as Akt modulation affects downstream components critical for olfactory receptor activity. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB-431542 inhibits TGF-β type I receptor, influencing the TGF-β signaling pathway. By modulating this pathway, the chemical indirectly affects Olfr659, as TGF-β-related processes play a role in regulating olfactory receptor expression and function. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
MK-2206 is an Akt inhibitor disrupting the PI3K/Akt pathway. By targeting this key signaling cascade, the chemical indirectly hampers Olfr659 function, as Akt modulation affects downstream components critical for olfactory receptor activity. | ||||||