Olfr658 Inhibitors
Olfr658, a member of the olfactory receptor family, serves as a critical component in the complex system of olfaction. Positioned on the surface of olfactory sensory neurons, Olfr658 functions as a G protein-coupled receptor (GPCR) that plays a central role in the detection and transduction of odorant signals. As an integral part of the olfactory system, Olfr658 is finely tuned to recognize a diverse array of odorant molecules, contributing to the intricate process of odor perception. Its specificity in binding to distinct odorants enables Olfr658 to initiate signaling cascades, ultimately leading to the generation of neural signals that contribute to the perception of various smells.
Inhibition of Olfr658 involves the modulation of specific cellular pathways crucial for its normal functioning. Various chemicals act as inhibitors by targeting key signaling cascades associated with Olfr658 activity. For instance, inhibition of the PI3K/Akt pathway disrupts downstream components essential for proper olfactory receptor functioning, indirectly impacting Olfr658. Similarly, interference with the MAPK/ERK pathway alters downstream elements crucial for normal olfactory receptor activity, leading to indirect inhibition of Olfr658. Furthermore, inhibitors acting on TGF-β signaling pathways can indirectly affect Olfr658, highlighting the intricate network of cellular processes that contribute to olfactory receptor regulation. The modulation of these pathways, orchestrated by various chemical inhibitors, provides insights into the regulatory mechanisms governing Olfr658, shedding light on the nuanced interplay within olfactory sensory neurons and the potential avenues for influencing receptor dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib inhibits the proteasome, affecting the degradation of proteins involved in olfactory receptor regulation. By disrupting protein turnover, this chemical indirectly hampers Olfr658, as proper receptor functioning relies on dynamic protein expression levels within sensory neurons. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, a key enzyme in the PI3K/Akt pathway. By disrupting this pathway, the chemical indirectly affects Olfr658, as Akt modulation influences downstream components essential for proper olfactory receptor functioning. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK1/2 inhibitor disrupting the MAPK/ERK pathway. Its interference with this pathway indirectly impacts Olfr658, as downstream components crucial for normal olfactory receptor activity are modulated, leading to receptor inhibition. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB-431542 inhibits TGF-β type I receptor, influencing the TGF-β signaling pathway. By modulating this pathway, the chemical indirectly affects Olfr658, as TGF-β-related processes play a role in regulating olfactory receptor expression and function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin acts as a PI3K inhibitor, disrupting the PI3K/Akt pathway. This interference influences olfactory signaling cascades, leading to indirect inhibition of Olfr658 by modulating crucial components downstream of the receptor. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK1 inhibitor disrupting the MAPK/ERK pathway. Its interference with this pathway indirectly impacts Olfr658, as downstream components crucial for normal olfactory receptor activity are modulated, leading to receptor inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB-203580 inhibits p38 MAPK, a kinase involved in various cellular processes. Its interference with the MAPK pathway indirectly impacts Olfr658, disrupting the downstream signaling required for normal olfactory receptor activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor disrupting the JNK pathway. Its impact on this pathway indirectly influences Olfr658 by altering downstream components crucial for normal olfactory receptor activity and signaling cascades. | ||||||
AZD5363 | 1143532-39-1 | sc-503190 | 5 mg | $309.00 | ||
AZD5363 is an Akt inhibitor disrupting the PI3K/Akt pathway. By targeting this key signaling cascade, the chemical indirectly hampers Olfr658 function, as Akt modulation affects downstream components critical for olfactory receptor activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a kinase in the mTOR pathway. Its modulation of this pathway indirectly influences Olfr658 by altering downstream components essential for proper olfactory receptor activity and signaling cascades. | ||||||