Olfr657 Inhibitors
Olfr657, an olfactory receptor, plays a pivotal role in the intricate process of olfaction. As a G protein-coupled receptor (GPCR) embedded in the olfactory sensory neurons, Olfr657 is fundamental for detecting and transducing odorant signals, contributing significantly to the olfactory system's overall function. These receptors are integral to the initial steps of odor perception, whereby they bind to specific odorant molecules, initiating a cascade of events leading to the generation of neural signals interpreted as distinct smells. Olfr657, like other olfactory receptors, is highly specialized in recognizing diverse odorants, showcasing the exquisite specificity essential for discriminating between an extensive array of chemical compounds. Inhibition of Olfr657 involves targeting key cellular pathways associated with its signaling cascade. Various chemicals act as inhibitors by influencing specific pathways indirectly linked to Olfr657 function. For instance, compounds targeting the PI3K/Akt pathway disrupt downstream components critical for proper olfactory receptor activity, thereby indirectly inhibiting Olfr657. Similarly, modulation of the MAPK/ERK pathway impacts the olfactory signaling cascade, influencing Olfr657 through alterations in downstream elements crucial for receptor function. Additionally, inhibitors acting on TGF-β signaling pathways can indirectly affect Olfr657, highlighting the intricate network of cellular processes that contribute to olfactory receptor regulation.
Understanding the nuanced mechanisms of Olfr657 inhibition requires an appreciation of the interconnected signaling pathways within olfactory sensory neurons. These chemicals, through their targeted actions, perturb the delicate balance of cellular processes associated with olfactory receptor function. The inhibition of Olfr657 is not a singular event but a result of intricate interactions within the olfactory signaling network. By elucidating these pathways and their modulation, researchers gain insights into the regulatory mechanisms governing olfaction, opening avenues for further exploration of olfactory receptor dynamics and potential applications in related fields.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone inhibits Olfr657 by disrupting mitochondrial complex I, reducing ATP production. This inhibition leads to impaired cellular respiration, impacting the olfactory signaling cascade and suppressing Olfr657 activity. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $178.00 $325.00 | 67 | |
MK-2206 is an Akt inhibitor disrupting the PI3K/Akt pathway. By targeting this key signaling cascade, the chemical indirectly hampers Olfr657 function, as Akt modulation affects downstream components critical for olfactory receptor activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB-203580 inhibits p38 MAPK, a kinase involved in various cellular processes. Its interference with the MAPK pathway indirectly impacts Olfr657, disrupting the downstream signaling required for normal olfactory receptor functioning. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin acts as a PI3K inhibitor, disrupting the PI3K/Akt pathway. This interference influences olfactory signaling cascades, leading to indirect inhibition of Olfr657 by modulating crucial components downstream of the receptor. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB-431542 inhibits TGF-β type I receptor, influencing the TGF-β signaling pathway. By modulating this pathway, the chemical indirectly affects Olfr657, as TGF-β-related processes play a role in regulating olfactory receptor expression and function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor disrupting the JNK pathway. Its impact on this pathway indirectly influences Olfr657 by altering downstream components crucial for normal olfactory receptor activity and signaling cascades. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, a key enzyme in the PI3K/Akt pathway. By disrupting this pathway, the chemical indirectly affects Olfr657, as Akt modulation influences downstream components essential for proper olfactory receptor functioning. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK1/2 inhibitor disrupting the MAPK/ERK pathway. Its interference with this pathway indirectly impacts Olfr657, as downstream components crucial for normal olfactory receptor activity are modulated, leading to receptor inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a kinase in the mTOR pathway. Its modulation of this pathway indirectly influences Olfr657 by altering downstream components essential for proper olfactory receptor activity and signaling cascades. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK1 inhibitor disrupting the MAPK/ERK pathway. Its interference with this pathway indirectly impacts Olfr657, as downstream components crucial for normal olfactory receptor activity are modulated, leading to receptor inhibition. | ||||||