Olfr566 Activators
Olfr566, a member of the olfactory receptor family, plays a crucial role in mediating the sense of smell in organisms. This gene encodes a receptor protein located on the cell membranes of olfactory sensory neurons in the nasal epithelium. The primary function of Olfr566 is to detect specific odorants present in the environment, enabling organisms to perceive and discriminate various scents. It achieves this by initiating a series of biochemical events upon interaction with odor molecules. Olfr566's activation is a pivotal step in the olfactory signal transduction pathway, which ultimately leads to the perception of distinct odors. Activation of Olfr566 occurs through a well-coordinated cascade of events. When odor molecules bind to Olfr566 receptors on the olfactory sensory neuron's surface, it triggers a conformational change in the receptor protein. This change is essential for initiating downstream signaling pathways. The initial step involves the activation of a G-protein associated with Olfr566, which, in turn, activates the enzyme adenylate cyclase. Adenylate cyclase catalyzes the conversion of adenosine triphosphate (ATP) into cyclic adenosine monophosphate (cAMP). Increased levels of cAMP serve as second messengers that activate protein kinase A (PKA), a key player in olfactory signal transduction.
Activation of PKA leads to the phosphorylation of various target proteins, including ion channels and effector enzymes. These phosphorylation events modulate ion fluxes across the olfactory sensory neuron's membrane, resulting in membrane depolarization. This depolarization, known as the receptor potential, is a critical step in the transduction of olfactory signals. It ultimately triggers action potentials that propagate along the neuron and transmit the olfactory information to the brain for further processing and perception. Olfr566's activation is thus a pivotal component of the intricate olfactory system, allowing organisms to detect and discriminate a wide range of odorants in their environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, also known as isoprenaline, activates Olfr566 by binding to its receptor and initiating a downstream signaling cascade, resulting in the functional activation of the Olfr566 protein. | ||||||
Carbachol | 51-83-2 | sc-202092 sc-202092A sc-202092C sc-202092D sc-202092B sc-202092E | 1 g 10 g 25 g 50 g 100 g 250 g | $122.00 $281.00 $388.00 $683.00 $1428.00 $3060.00 | 12 | |
Carbachol directly activates Olfr566 by binding to its receptor and triggering intracellular signaling events, ultimately resulting in the functional activation of the Olfr566 protein. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP activates Olfr566 through its role as a cyclic AMP analog, promoting the activation of protein kinase A (PKA), which in turn activates Olfr566 via phosphorylation, leading to its functional activation. | ||||||
Aminophylline | 317-34-0 | sc-252368 | 25 g | $37.00 | ||
Aminophylline indirectly activates Olfr566 by inhibiting phosphodiesterase, increasing intracellular cAMP levels, and subsequently activating Olfr566 via the cAMP-dependent pathway, resulting in its functional activation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram indirectly activates Olfr566 by inhibiting phosphodiesterase 4 (PDE4), leading to increased cAMP levels and subsequent activation of Olfr566 via the cAMP-dependent pathway, resulting in functional activation. | ||||||
α-Methyl-D,L-tyrosine | 620-30-4 | sc-207231 | 2.5 g | $194.00 | ||
Alpha-Methyltyrosine activates Olfr566 by influencing the synthesis of norepinephrine, which, when binding to Olfr566 receptors, initiates downstream signaling pathways and leads to the functional activation of Olfr566. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
Salbutamol activates Olfr566 by binding to its receptor and stimulating adenylate cyclase, leading to increased cAMP levels, which activate Olfr566 through the cAMP-dependent pathway, resulting in functional activation. | ||||||
PD 116,948 | 102146-07-6 | sc-200115 sc-200115A | 25 mg 100 mg | $124.00 $228.00 | 6 | |
PD 116,948 activates Olfr566 by antagonizing adenosine receptors, thereby preventing the inhibition of adenylate cyclase, increasing cAMP levels, and ultimately activating Olfr566 through the cAMP-dependent pathway, resulting in functional activation. | ||||||
Hexamethonium chloride | 60-25-3 | sc-263383 | 5 g | $32.00 | ||
Hexamethonium chloride indirectly activates Olfr566 by inhibiting nicotinic acetylcholine receptors, reducing the influence of inhibitory pathways, and ultimately leading to the functional activation of Olfr566 through enhanced olfactory signal transduction. | ||||||
N-Methyl-D-Aspartic acid (NMDA) | 6384-92-5 | sc-200458 sc-200458A | 50 mg 250 mg | $109.00 $369.00 | 2 | |
N-Methyl-D-Aspartate activates Olfr566 by modulating glutamate receptors, initiating intracellular signaling events that result in the functional activation of Olfr566 through specific pathways associated with glutamate receptor activation. | ||||||