Olfr521 Inhibitors
Olfr521, a vital olfactory receptor, contributes to the detection and transduction of specific odorants within the olfactory system. This receptor plays a pivotal role in signal transduction, converting external chemical cues into intracellular responses that lead to the perception of odors. The intricate network of signaling pathways associated with Olfr521 includes the cholinergic system, cyclic nucleotide signaling, JNK, PI3K-AKT, MAPK/ERK, mTOR, p38 MAPK, and NF-κB pathways. The inhibition of Olfr521 involves targeted modulation of these pathways. Malathion disrupts the cholinergic system by inhibiting acetylcholinesterase, indirectly impacting Olfr521. Zaprinast, a PDE5 inhibitor, modifies cGMP levels, indirectly influencing Olfr521 through cyclic nucleotide signaling pathways. SP600125 and Wortmannin target JNK and PI3K pathways, respectively, altering downstream signaling and leading to changes in Olfr521 expression. PD98059 and LY294002 affect the MAPK/ERK and PI3K-AKT pathways, respectively, indirectly modulating Olfr521.
Rapamycin, SB-203580, U0126, and VX-745 target mTOR, p38 MAPK, MEK, and p38 MAPK pathways, respectively, influencing Olfr521 through alterations in cellular processes and gene expression. BMS-345541 inhibits IKK, impacting the NF-κB pathway and indirectly modulating Olfr521. AZD5363, an AKT inhibitor, perturbs the PI3K-AKT pathway, leading to changes in gene expression and olfactory receptor regulation. In summary, the inhibition of Olfr521 involves a sophisticated interplay of specific biochemical and cellular pathways, ultimately influencing the receptor's expression and function within the olfactory system.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
PDE5 inhibitor affecting cGMP levels. Indirectly modulates Olfr521 by modifying cyclic nucleotide signaling pathways, leading to altered gene expression patterns within the olfactory system. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor disrupting the JNK signaling pathway. Influences Olfr521 by modulating downstream effectors, leading to altered gene expression profiles and functional changes in olfactory receptor activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor affecting the PI3K-AKT pathway. Indirectly modulates Olfr521 by interfering with intracellular signaling cascades, resulting in changes in gene expression and olfactory receptor regulation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor targeting the MAPK/ERK pathway. Influences Olfr521 indirectly by disrupting key signaling events, leading to modified gene expression patterns and functional regulation of olfactory receptors. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor impacting the PI3K-AKT pathway. Indirectly influences Olfr521 by perturbing intracellular signaling, resulting in modified gene expression within the olfactory sensory neurons. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor affecting the mTOR signaling pathway. Indirectly impacts Olfr521 by influencing cellular processes, resulting in altered gene expression patterns and functional modulation of olfactory receptors. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAPK inhibitor disrupting the MAPK pathway. Influences Olfr521 by inhibiting a downstream signaling component, resulting in altered cellular responses and modulation of olfactory receptor expression. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
MEK inhibitor targeting the MAPK/ERK pathway. Influences Olfr521 indirectly by disrupting a key signaling cascade, leading to altered expression patterns and functional regulation of olfactory receptors. | ||||||
VX 745 | 209410-46-8 | sc-361401 sc-361401A | 10 mg 50 mg | $183.00 $842.00 | 4 | |
p38 MAPK inhibitor disrupting the MAPK pathway. Influences Olfr521 by inhibiting downstream components, leading to altered cellular responses and modulation of olfactory receptor expression. | ||||||
BMS-345541 | 445430-58-0 | sc-221741 | 1 mg | $306.00 | 1 | |
IKK inhibitor affecting the NF-κB signaling pathway. Indirectly modulates Olfr521 by influencing downstream effectors, leading to altered gene expression profiles and functional changes in olfactory receptor activity. | ||||||