Olfr519 Inhibitors
Olfr519, a member of the olfactory receptor family, plays a pivotal role in the complex process of olfaction. Located in the sensory neurons of the olfactory epithelium, Olfr519 is essential for detecting specific odorants and initiating intracellular signaling events that lead to the perception of smell. As a G protein-coupled receptor (GPCR), Olfr519 is intricately linked to various signaling pathways, including GPCR, TGF-β, PI3K-Akt, MAPK, and mTOR pathways, reflecting its involvement in diverse intracellular responses to external olfactory stimuli.
The inhibition of Olfr519 involves a nuanced interplay of chemical inhibitors targeting key components of these signaling pathways. For example, inhibitors like Bisphenol A disrupt the olfactory receptor signaling cascade by interfering with cAMP production downstream of Olfr519. Similarly, compounds such as SB-431542 act as TGF-β receptor inhibitors, impacting the TGF-β signaling pathway and indirectly influencing Olfr519 expression. The modulation of PI3K-Akt, MAPK, and mTOR pathways by specific inhibitors further highlights the intricate mechanisms underlying Olfr519 inhibition. The effectiveness of these inhibitors lies in their ability to perturb the finely tuned balance of signaling events, resulting in altered expression levels of Olfr519 and, consequently, influencing olfactory signal transduction. In summary, Olfr519 plays a crucial role in olfactory perception, and its inhibition involves a sophisticated network of chemical inhibitors targeting specific components of signaling pathways. The diverse range of inhibitors identified underscores the complexity of olfactory signal transduction and provides valuable insights into the regulatory mechanisms governing Olfr519 expression and function.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A disrupts the olfactory receptor signaling cascade associated with Olfr519 by interfering with downstream cAMP production, leading to indirect inhibition of Olfr519. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB-431542 acts as a TGF-β receptor inhibitor, impacting the TGF-β signaling pathway. By modulating this pathway, it indirectly influences Olfr519 expression, serving as an indirect inhibitor. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits PI3K, a key player in the PI3K-Akt signaling pathway. By disrupting this pathway, Wortmannin indirectly affects Olfr519 expression, acting as an indirect inhibitor. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK, a component of the MAPK signaling pathway. Its action on this pathway indirectly influences Olfr519 expression, serving as an indirect inhibitor of the target olfactory receptor. | ||||||
JNK Inhibitor VIII | 894804-07-0 | sc-202673 | 5 mg | $267.00 | 2 | |
JNK Inhibitor VIII disrupts the JNK signaling pathway, indirectly impacting Olfr519 expression. This indirect inhibition is mediated through the modulation of the c-Jun N-terminal kinase pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a crucial protein in the mTOR signaling pathway. By affecting this pathway, Rapamycin indirectly influences Olfr519 expression, serving as an indirect inhibitor. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, affecting the PI3K-Akt signaling pathway. Its impact on this pathway indirectly leads to Olfr519 inhibition, serving as an indirect inhibitor of the olfactory receptor. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits MEK, an upstream regulator in the MAPK signaling pathway. By disrupting this pathway, PD98059 indirectly influences Olfr519 expression, serving as an indirect inhibitor. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 inhibits JNK, disrupting the JNK signaling pathway. Its action on this pathway indirectly affects Olfr519 expression, acting as an indirect inhibitor of the target olfactory receptor. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $105.00 $153.00 | 4 | |
LY364947 functions as a TGF-β receptor inhibitor, impacting the TGF-β signaling pathway. By modulating this pathway, it indirectly influences Olfr519 expression, serving as an indirect inhibitor. | ||||||