Olfr497 Inhibitors
Olfr497, an integral member of the olfactory receptor protein family, plays a pivotal role in orchestrating the complex process of smell perception. Operating within the intricate framework of the olfactory system, Olfr497 is a G-protein-coupled receptor (GPCR) that engages with odorant molecules in the nasal environment. This interaction initiates a sophisticated neuronal response, ultimately leading to the conscious perception of distinct smells. Structurally, Olfr497 shares a 7-transmembrane domain architecture with neurotransmitter and hormone receptors, a hallmark feature of the GPCR family. The coding-exon genes governing olfactory receptors contribute to the remarkable diversity within this gene family, constituting the largest such family in the genome. Notably, the nomenclature assigned to olfactory receptor genes and proteins for this organism remains independent of other organisms, emphasizing the unique and species-specific nature of olfactory signaling.
The inhibition of Olfr497 involves a diverse array of chemical agents that can act either directly or indirectly to modulate its function. Direct inhibitors exert their influence by specifically targeting components of signaling pathways associated with Olfr497. For instance, inhibitors like MEK inhibitors or p38 MAPK inhibitors directly interfere with the MAPK pathway, disrupting downstream elements crucial for olfactory signal transduction. On the other hand, indirect inhibitors operate by influencing cellular processes related to Olfr497 function. Calcium channel blockers or PI3K inhibitors may impact Olfr497 by modulating intracellular calcium levels or disrupting the PI3K-Akt pathway, respectively. These alterations in cellular processes ultimately impact G-protein-mediated transduction, thereby influencing the neuronal response to odorant signals and potentially altering the perception of odors in the olfactory system. The intricacies of these inhibitory mechanisms highlight the complex web of signaling pathways involved in olfactory signal transduction and provide valuable insights into the regulatory networks governing Olfr497 within the molecular landscape of smell perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Chelerythrine, a PKC inhibitor, may directly inhibit Olfr497 by disrupting PKC-mediated signaling pathways. Its interference with this pathway could impact G-protein-coupled receptor function, altering the neuronal response to odorant signals in the olfactory system. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126, a MEK inhibitor, directly inhibits the MAPK pathway. By disrupting this pathway, it may influence downstream elements affecting Olfr497, potentially altering G-protein-coupled receptor signaling and impacting olfactory perception. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
PTX (Pertussis toxin) inhibits G-protein signaling. Olfr497, being a GPCR, may be indirectly affected, as pertussis toxin disrupts G-protein-mediated transduction. This interference could alter the neuronal response to odorant signals in the olfactory system. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, may indirectly influence Olfr497 by inhibiting the PI3K-Akt pathway. Modulating this pathway could impact cellular processes associated with olfactory signal transduction, potentially affecting the perception of odors. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine, a calcium channel blocker, could indirectly impact Olfr497 by modulating intracellular calcium levels. Changes in calcium signaling may affect G-protein-mediated transduction and alter the neuronal response to odorant molecules, impacting olfactory perception. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, directly targets the MAPK pathway. Inhibition of this pathway may affect downstream elements involved in olfactory signal transduction, potentially influencing Olfr497 and altering the perception of odors in the olfactory system. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a PI3K inhibitor, could indirectly influence Olfr497 by disrupting the PI3K-Akt pathway. Modulating this pathway may impact cellular processes associated with olfactory signal transduction, potentially affecting the perception of odors. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin, a SERCA inhibitor, may indirectly inhibit Olfr497 by disrupting calcium homeostasis. Changes in intracellular calcium levels could influence G-protein-mediated transduction, altering the neuronal response to odorant signals and impacting olfactory perception. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93, a CaMKII inhibitor, may indirectly affect Olfr497 by modulating calcium/calmodulin-dependent signaling pathways. Disruption of these pathways could impact G-protein-coupled receptor function, potentially altering the neuronal response to odorant signals in the olfactory system. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF109203X, a PKC inhibitor, may indirectly influence Olfr497 by modulating PKC-mediated signaling pathways. Disruption of these pathways could impact G-protein-coupled receptor function, potentially altering the neuronal response to odorant signals in the olfactory system. | ||||||