Olfr473 Inhibitors
Olfr473, a crucial member of the olfactory receptor family, orchestrates the initiation of neuronal responses essential for the perception of diverse odors. As a G-protein-coupled receptor (GPCR) with a 7-transmembrane domain structure, Olfr473 shares structural characteristics with neurotransmitter and hormone receptors. Its primary function involves the recognition and G protein-mediated transduction of odorant signals within the nasal cavity, contributing significantly to the intricacies of olfactory experiences.
The inhibition of Olfr473 entails a nuanced interplay of various chemical inhibitors targeting specific cellular pathways essential for olfactory signal transduction. Compounds directly hindering muscarinic receptor activity, disrupting JNK and PI3K-dependent events, inhibiting vesicle trafficking, modulating CaMKII and PKA activities, and interfering with ryanodine receptors collectively contribute to Olfr473 inhibition. These intricate mechanisms highlight the depth of understanding required to unravel the complexities of olfactory receptor function and underscore the interplay of molecular events crucial for regulating Olfr473's role in olfactory perception. Exploring these mechanisms serves as a foundation for advancing our understanding of olfactory processes, unraveling the molecular intricacies governing the perception of diverse odors mediated by Olfr473 in this organism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Scopolamine | 51-34-3 | sc-473216 sc-473216A sc-473216B | 100 mg 500 mg 1 g | $172.00 $506.00 $786.00 | 2 | |
Scopolamine, a muscarinic acetylcholine receptor antagonist, directly inhibits Olfr473 by binding to muscarinic receptors. This disrupts G protein-mediated signal transduction, hindering the recognition and transduction of odorant signals within the olfactory system. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK), SP600125 indirectly inhibits Olfr473 by disrupting the JNK signaling pathway. This interference impacts G protein-mediated transduction of odorant signals, altering the receptor's ability to initiate a neuronal response and perceive odors effectively. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A phosphoinositide 3-kinase (PI3K) inhibitor, LY294002 influences intracellular signaling pathways crucial for Olfr473 function. By disrupting PI3K-dependent events, this chemical indirectly inhibits Olfr473, impairing the normal transduction of odorant signals and negatively impacting G protein-mediated responses of the olfactory receptor. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a phosphoinositide 3-kinase (PI3K) inhibitor, directly influences intracellular signaling pathways crucial for Olfr473 function. By disrupting PI3K-dependent events, this chemical inhibits Olfr473, impairing the normal transduction of odorant signals and negatively impacting G protein-mediated responses of the olfactory receptor. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
A CaMKII inhibitor, KN-93 modulates CaMKII-dependent processes in olfactory signal transduction. This chemical indirectly inhibits Olfr473 by interfering with calcium-calmodulin-dependent kinase II (CaMKII), disrupting downstream events crucial for G protein-mediated transduction of odorant signals. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
A selective MEK inhibitor, U0126 disrupts the MAPK pathway. This compound indirectly inhibits Olfr473 by interfering with MAPK-dependent events, negatively impacting G protein-mediated transduction of odorant signals. The disruption occurs at the level of MEK, influencing downstream events crucial for olfactory perception. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene, a ryanodine receptor antagonist, indirectly inhibits Olfr473 by disrupting calcium-dependent processes. This disruption affects the intracellular calcium levels crucial for olfactory signal transduction, impairing the recognition and transduction of odorant signals by Olfr473 within the nasal cavity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059, a selective MEK inhibitor, disrupts the MAPK pathway. This compound indirectly inhibits Olfr473 by interfering with MAPK-dependent events, negatively impacting G protein-mediated transduction of odorant signals. The disruption occurs at the level of MEK, influencing downstream events crucial for olfactory perception. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
An inhibitor of vesicle trafficking, Brefeldin A disrupts Golgi apparatus function and indirectly inhibits Olfr473. This disruption affects the proper localization and functioning of olfactory receptors, impairing the recognition and transduction of odorant signals within the nasal cavity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
An inhibitor of p38 mitogen-activated protein kinase (MAPK), SB-203580 indirectly inhibits Olfr473 by disrupting the p38 MAPK pathway. This disruption negatively impacts G protein-mediated transduction of odorant signals, altering the receptor's ability to initiate a neuronal response and perceive odors effectively. | ||||||