Olfr464 Inhibitors
Olfr464 stands as a crucial player in the intricate orchestration of olfactory perception, serving as a key member of the olfactory receptor family. The primary function of Olfr464 lies in its role as a G-protein-coupled receptor (GPCR), specifically designed for the recognition and transduction of odorant signals within the nasal cavity. With a structure characterized by a 7-transmembrane domain, Olfr464 shares commonalities with neurotransmitter and hormone receptors. Its participation in the G protein-mediated transduction of odorant signals contributes significantly to the initiation of neuronal responses, ultimately culminating in the perception of distinct smells. As a member of a large gene family with single coding-exon genes, Olfr464's nomenclature remains independent within this organism, emphasizing its unique role in the olfactory system.
The inhibition of Olfr464 involves a sophisticated array of mechanisms targeting specific cellular pathways crucial for olfactory signal transduction. These mechanisms encompass modulation of the cAMP signaling pathway through phosphodiesterase inhibition, enhancement of cAMP production via adenylyl cyclase activation, disruption of the MAPK pathway through specific inhibitors, interference with ionotropic processes via ion channel blockers, inhibition of G proteins, modulation of calcium channels, and manipulation of PKC signaling pathways. Each of these interventions collectively contributes to the intricate inhibition of Olfr464, impacting the receptor's ability to recognize and transduce odorant signals effectively. This comprehensive approach highlights the depth of understanding required to unravel the complexities of olfactory receptor function and underscores the intricate interplay of molecular events essential for the regulation of Olfr464's role in olfactory perception. The exploration of these intricate mechanisms serves as a foundation for advancing our understanding of olfactory processes, shedding light on the molecular intricacies that govern the perception of diverse odors in this organism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram, a phosphodiesterase 4 (PDE4) inhibitor, modulates the cAMP signaling pathway. By inhibiting PDE4 activity, it increases intracellular cAMP levels, negatively affecting the olfactory transduction process. This disruption hampers the G protein-mediated transduction of odorant signals by Olfr464. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126, a mitogen-activated protein kinase (MAPK) inhibitor targeting the ERK pathway, disrupts the downstream signaling events of Olfr464. This compound influences neuronal responses to odorant molecules by specifically targeting the MAPK pathway, indirectly inhibiting the G protein-coupled receptor function of Olfr464. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
Amiloride, an ion channel blocker, interferes with the normal ion flux associated with olfactory signal transduction. By disrupting the ionotropic processes, this chemical indirectly inhibits Olfr464, impairing its ability to initiate a neuronal response to odorant molecules. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis Toxin, a G protein inhibitor, specifically targets the Gα subunit involved in olfactory signal transduction. This compound disrupts the G protein-mediated transduction process, leading to the indirect inhibition of Olfr464. The interference occurs at the molecular level, impacting the receptor's ability to recognize odorant signals. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil, a calcium channel antagonist, interferes with intracellular calcium levels. By disrupting calcium-mediated signaling events, this chemical indirectly inhibits Olfr464, as calcium plays a crucial role in the modulation of olfactory receptor proteins. The disruption affects the receptor's ability to transduce odorant signals effectively. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1, a protein kinase C (PKC) activator, modulates the PKC signaling pathway. This chemical indirectly inhibits Olfr464 by influencing downstream PKC-mediated events, disrupting the normal transduction of odorant signals. The altered phosphorylation events impair the receptor's ability to initiate a neuronal response to odorants. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol, a microtubule-stabilizing agent, disrupts microtubule dynamics involved in intracellular transport. By affecting cellular processes related to olfactory signal transduction, this chemical indirectly inhibits Olfr464, influencing the receptor's ability to initiate a neuronal response to odorant molecules. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074, a Raf-1 kinase inhibitor, targets the Raf-MEK-ERK pathway. This compound disrupts downstream signaling events associated with Olfr464, indirectly inhibiting the G protein-coupled receptor function. The interference occurs at the level of Raf-1 kinase, impacting the transduction of odorant signals. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93, a CaMKII inhibitor, modulates CaMKII-dependent processes in olfactory signal transduction. This chemical indirectly inhibits Olfr464 by interfering with calcium-calmodulin-dependent kinase II (CaMKII), disrupting downstream events crucial for G protein-mediated transduction of odorant signals. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM, a calcium chelator, reduces intracellular calcium levels. By chelating calcium ions, this chemical indirectly inhibits Olfr464, as calcium is integral to the modulation of olfactory receptor proteins. The disruption affects the receptor's ability to transduce odorant signals effectively. | ||||||