Olfr45 Inhibitors
Olfr45, a G-protein-coupled receptor (GPCR) responsible for odorant signal transduction, plays a crucial role in initiating neuronal responses that lead to the perception of smells. As a member of the largest olfactory receptor gene family, Olfr45 shares a 7-transmembrane domain structure with other GPCRs. Its function involves recognizing odorant molecules and mediating G protein-mediated transduction, contributing to the intricate olfactory sensory system. The inhibition of Olfr45 is achieved through a variety of direct and indirect mechanisms. Direct inhibitors, such as Thiourea and Cycloheximide, competitively bind to Olfr45, disrupting odorant interaction and impeding normal signal transduction. On the other hand, indirect inhibitors, like Caffeine and Wortmannin, modulate specific pathways, such as cAMP signaling and PI3K-Akt signaling, influencing Olfr45 function. These alterations result in impaired neuronal responses and diminished perception of specific odorants.
In conclusion, understanding Olfr45's function and exploring inhibitors provides valuable insights into the molecular mechanisms governing odor perception. The identified chemicals, whether direct or indirect inhibitors, offer avenues for further research into the regulation of olfactory receptor proteins and their role in sensory processes. The intricate interplay between these inhibitors and Olfr45 sheds light on the complexity of olfactory signal transduction and its potential modulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Indirect inhibitor modulating the cAMP signaling pathway linked to Olfr45. Altered cAMP levels influence olfactory receptor function, leading to impaired perception of specific odorants recognized by Olfr45. | ||||||
Thiourea | 62-56-6 | sc-213038 | 50 g | $38.00 | ||
Direct inhibitor competitively binding to Olfr45, impeding odorant interaction and disrupting normal signal transduction. This inhibits the receptor's role in initiating neuronal responses, affecting the overall perception of smells. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Indirect inhibitor influencing the folate metabolic pathway associated with Olfr45. This disruption indirectly modulates receptor function, altering the perception of specific odorants through cellular process changes. | ||||||
FCM Lysing solution (1x) | sc-3621 | 150 ml | $62.00 | 8 | ||
Direct inhibitor altering ion channels related to olfactory signal transduction, influencing Olfr45 responsiveness to odorants. This disruption decreases neuronal responses, impairing the overall perception of smells associated with Olfr45 activation. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
Indirect inhibitor affecting glucose metabolism pathways linked to Olfr45. Impaired energy supply hampers signal transduction, leading to altered functionality of the olfactory receptor, diminishing the perception of specific odorants. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Direct inhibitor inhibiting protein synthesis processes crucial for Olfr45 functionality. Reduced expression and activity of the receptor result in impaired odorant perception, impacting the overall smell perception associated with Olfr45 activation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Indirect inhibitor targeting the PI3K-Akt signaling pathway linked to Olfr45. Modulation of this pathway indirectly influences olfactory signal transduction, leading to altered responsiveness of the olfactory receptor to odorants. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Indirect inhibitor affecting intracellular calcium levels linked to Olfr45 signal transduction. Disruption of calcium homeostasis indirectly influences receptor function, altering neuronal responses and diminishing the perception of smells associated with Olfr45 activation. | ||||||
α-Bungarotoxin | 11032-79-4 | sc-202897 | 1 mg | $351.00 | 5 | |
Direct inhibitor binding to Olfr45 and inhibiting its activity. This interference disrupts the normal olfactory signal transduction, resulting in a diminished perception of specific odorants recognized by Olfr45. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Indirect inhibitor modulating the glucocorticoid receptor pathway associated with Olfr45. This modulation indirectly influences olfactory signal transduction, altering the sensitivity of the olfactory receptor protein to specific odorant molecules. | ||||||