Olfr381 Inhibitors
Or1e22, a member of the olfactory receptor family 1 subfamily E in Mus musculus, plays a pivotal role in initiating the neuronal response that leads to the perception of smell. As an olfactory receptor, Or1e22 is a G-protein-coupled receptor (GPCR) characterized by a 7-transmembrane domain structure. Its function involves the recognition of odorant molecules, triggering a cascade of events that ultimately result in the transmission of signals to the brain, leading to the perception of a specific smell.
The inhibition of Or1e22 involves targeting key components in the olfactory signaling pathway. For instance, inhibiting Protein Kinase C (PKC) disrupts phosphorylation events downstream of Or1e22, hindering the GPCR-mediated transduction of signals. Additionally, blocking Adenylyl Cyclase 3 (AC3) impairs cAMP production, disrupting the cAMP-dependent pathway associated with Or1e22 activation. Other inhibitors target crucial enzymes and proteins such as Phospholipase C (PLC), Gαolf, Calcium/Calmodulin-dependent Protein Kinase II (CaMKII), and Mitogen-Activated Protein Kinase (MAPK), influencing various stages of olfactory signal transduction. The general mechanisms of inhibition revolve around modulating these key elements to interfere with the cascade of events triggered by Or1e22 activation. This disruption impacts downstream signaling pathways, altering neuronal responses to odorant stimuli. For example, inhibition of MAPK interferes with the phosphorylation cascade, while disruption of CaMKII activity affects ion channels and synaptic transmission. The diversity of inhibitors reflects the intricate nature of the olfactory signaling pathway and provides avenues for studying and understanding the complexities of Or1e22 function and its modulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amitriptyline Hydrochloride | 549-18-8 | sc-210801 | 1 g | $196.00 | ||
Modulator of a specific signaling pathway associated with Or1e22. Alters a downstream molecule in the pathway, leading to indirect inhibition of Or1e22-mediated responses. | ||||||
Fenvalerate | 51630-58-1 | sc-24014 sc-24014A | 25 mg 100 mg | $78.00 $226.00 | 2 | |
Inhibitor impacting cellular processes linked to Or1e22. Modifies the membrane environment, affecting G protein-mediated transduction of odorant signals and suppressing the neuronal response. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Modulates a specific signaling pathway associated with Or1e22. Indirectly inhibits Or1e22 by influencing downstream molecules, disrupting the neuronal response triggered by the recognition of odorant signals. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
Impacts cellular processes linked to Or1e22. Alters membrane properties, affecting G protein-mediated transduction of odorant signals and suppressing the neuronal response through inhibition of Or1e22. | ||||||
Tropicamide | 1508-75-4 | sc-202371 | 100 mg | $31.00 | 3 | |
GPCR antagonist targeting the 7-transmembrane domain structure shared by olfactory receptors. Interferes with odorant signal transduction, leading to inhibition of the neuronal response triggered by Or1e22. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Modulator of a specific signaling pathway associated with Or1e22. Alters downstream molecules in the pathway, resulting in indirect inhibition of Or1e22-mediated responses. | ||||||
Trifluorothymidine | 70-00-8 | sc-222370 sc-222370A | 100 mg 1 g | $179.00 $500.00 | 1 | |
Inhibitor impacting cellular processes linked to Or1e22. Modifies the membrane environment, affecting G protein-mediated transduction of odorant signals and suppressing the neuronal response. | ||||||
Ondansetron | 99614-02-5 | sc-201127 sc-201127A | 10 mg 50 mg | $80.00 $326.00 | 1 | |
Disrupts GPCR function critical for olfactory receptor activity. Interferes with the 7-transmembrane domain structure, impeding the recognition and transduction of odorant signals by Or1e22. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $66.00 $280.00 $1300.00 | 11 | |
Modulates a specific signaling pathway associated with Or1e22. Indirectly inhibits Or1e22 by influencing downstream molecules, disrupting the neuronal response triggered by the recognition of odorant signals. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
GPCR antagonist targeting the 7-transmembrane domain structure shared by olfactory receptors. Interferes with odorant signal transduction, leading to inhibition of the neuronal response triggered by Or1e22. | ||||||