Molecular structure of Amitriptyline Hydrochloride, CAS Number: 549-18-8
Amitriptyline Hydrochloride (CAS 549-18-8)
Alternate Names:
3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine Hydrochloride
Application:
Amitriptyline Hydrochloride is an antidepressant with anticholinergic and sedative properties
CAS Number:
549-18-8
Molecular Weight:
313.86
Molecular Formula:
C20H24ClN
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Amitriptyline Hydrochloride is an amphiphilic tricyclic compound. It prevents the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline antagonizes cholinergic and alpha-1 adrenergic responses to bioactive amines. Amitriptyline Hydrochloride exhibits micellization and phase separation behavior in the presence of ionic and nonionic hydrotropes. Amitriptyline Hydrochloride and Hemoglobin interact through a static quenching mechanism. Its binding to Hemoglobin is spontaneous. The process involves hydrogen bonding and van der Waals interactions and occurs with a single binding site. Amitriptyline Hydrochloride, with a pKa of 9.4, primarily exists in its protonated form. Amitriptyline Hydrochloride has also been found to have antimicrobial activity.
Amitriptyline Hydrochloride (CAS 549-18-8) References
- Aqueous amphiphilic drug (amitriptyline hydrochloride)-bile salt mixtures at different temperatures. | Kabir-ud-Din, ., et al. 2011. Colloids Surf B Biointerfaces. 84: 285-91. PMID: 21349692
- Chemical stability of amitriptyline hydrochloride in oral liquid dosage forms. | Gupta, VD. 2009. Int J Pharm Compd. 11: 445-6. PMID: 23966529
- An Investigation on in vitro and in vivo Antimicrobial Properties of the Antidepressant: Amitriptyline Hydrochloride. | Mandal, A., et al. 2010. Braz J Microbiol. 41: 635-45. PMID: 24031539
- Hydrogen bonding-assisted interaction between amitriptyline hydrochloride and hemoglobin: spectroscopic and molecular dynamics studies. | Maurya, N., et al. 2017. J Biomol Struct Dyn. 35: 1367-1380. PMID: 27141981
- Stability of Allopurinol, Amitriptyline Hydrochloride, Carbamazepine, Domperidone, Isoniazid, Ketoconazole, Lisinopril, Naproxen, Paracetamol (Acetaminophen), and Sertraline Hydrochloride in SyrSpend SF PH4 Oral Suspensions. | Polonini, HC., et al. 2016. Int J Pharm Compd. 20: 426-434. PMID: 28339378
- Preparation and characterization of nano amitriptyline hydrochloride particles by spray freeze drying. | Hu, Y., et al. 2019. Nanomedicine (Lond). 14: 1521-1531. PMID: 31180256
- Investigation of micellar and interfacial phenomenon of amitriptyline hydrochloride with cationic ester-bonded gemini surfactant mixture in different solvent media. | Abdul Rub, M. 2020. PLoS One. 15: e0241300. PMID: 33156844
- Modulation of nociception by amitriptyline hydrochloride in the Speke's hinge-back tortoise (Kiniskys spekii). | Makau, CM., et al. 2021. Vet Med Sci. 7: 1034-1041. PMID: 33559977
- Dermal delivery of amitriptyline for topical analgesia. | Kung, CP., et al. 2022. Drug Deliv Transl Res. 12: 805-815. PMID: 33886076
- Stability-indicating liquid chromatography method development for assay and impurity profiling of amitriptyline hydrochloride in tablet dosage form and forced degradation study. | Boppy, NVVDP., et al. 2022. Biomed Chromatogr. 36: e5436. PMID: 35766584
- Physicochemical and Microbiological Stability of Amitriptyline Hydrochloride Oral Liquid Dosage Forms in PCCA Base, SuspendIt. | Pramar, YV., et al. 2022. Int J Pharm Compd. 26: 342-351. PMID: 35820140
- Stability of amitriptyline hydrochloride in a commercial aqueous solution. | Roman, R., et al. 1979. J Pharm Sci. 68: 1329-30. PMID: 512874
- Scalp dysesthesia. | Hoss, D. and Segal, S. 1998. Arch Dermatol. 134: 327-30. PMID: 9521031
Inhibitor of:
MGP, NNT, Olfr381, Olfr504, Olfr57, sorcin, SorCS1, SV2C, VAP-1, and Vmn2r67.Activator of:
6530403A03Rik, EDG-2, KCNQ2, Leu-enkephalin, PNMAL1, and RyR-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Amitriptyline Hydrochloride, 1 g | sc-210801 | 1 g | $196.00 |