Olfr368 Inhibitors
Or5c1, an olfactory receptor in Mus musculus, functions as a key player in the olfactory system, initiating a neuronal response upon interaction with odorant molecules. Belonging to the G-protein-coupled receptor (GPCR) family, it shares a structural domain with neurotransmitter and hormone receptors. The large gene family is exclusive to the organism, emphasizing its unique role in odor perception. Or5c1's involvement in G protein-mediated transduction of odorant signals highlights its significance in the complex olfactory process.
The inhibition of Or5c1 involves intricate cellular pathways. Through the identified chemicals, we target specific pathways associated with the protein. Disruption of vesicular transport by Brefeldin A indirectly affects Or5c1, showcasing the interconnected nature of cellular processes. Inhibitors like LY294002 and Wortmannin interfere with the PI3K/AKT pathway, impacting downstream signaling events linked to Or5c1. MEK inhibitors, including U0126 and Trametinib, disrupt the MAPK pathway, influencing the target protein indirectly. Additionally, inhibitors like Rapamycin and GDC-0994 affect mTOR and ERK within their respective pathways, further modulating Or5c1 function. SB203580, SP600125, and PD98059 target specific MAPK pathway components (p38 MAPK, JNK, and MEK, respectively), indirectly affecting Or5c1 signaling. SB431542, an inhibitor of the TGF-beta type I receptor, showcases the complexity of indirect inhibition by targeting a pathway linked to the cellular dynamics of Or5c1. In summary, the inhibition of Or5c1 involves a strategic approach targeting various cellular pathways associated with its function. The identified inhibitors disrupt key signaling cascades, indirectly influencing the intricate processes orchestrated by Or5c1 in the olfactory system of Mus musculus.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts the vesicular transport system, specifically inhibiting protein transport from the endoplasmic reticulum to the Golgi apparatus. This disruption indirectly hampers Or5c1 function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that interferes with the PI3K/AKT signaling pathway. By inhibiting this pathway, downstream effects negatively influence Or5c1 signaling, serving as an indirect inhibitor. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that acts on the MAPK pathway. Its interference with this pathway leads to altered downstream signaling, indirectly influencing Or5c1 function within the cellular context. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits PI3K, disrupting the PI3K/AKT pathway. This disruption indirectly affects Or5c1 by altering downstream signaling events related to cellular responses initiated by the target protein. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. Its impact on the p38 MAPK pathway indirectly influences Or5c1, as this protein is intertwined with cellular responses modulated by p38 MAPK signaling. | ||||||
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $112.00 $163.00 $928.00 | 19 | |
Trametinib, a MEK inhibitor, disrupts the MAPK pathway. This interference with the pathway indirectly affects Or5c1, as its signaling is intricately connected to the overall dynamics of the MAPK cascade. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a central component of the mTOR pathway. By disrupting this pathway, Rapamycin indirectly influences Or5c1, as mTOR is involved in cellular processes connected to the target protein. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor, affecting the JNK signaling pathway. Its interference with this pathway has downstream effects that indirectly influence Or5c1 function within the cellular context. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits MEK within the MAPK pathway. Its impact on this pathway indirectly influences Or5c1, as MEK is a crucial component in the cascade of events that regulate the target protein's signaling. | ||||||
LY3214996 | 1951483-29-6 | sc-507299 | 5 mg | $260.00 | ||
LY3214996 is a potent and selective ERK inhibitor, disrupting the MAPK pathway. Its interference with the pathway indirectly influences Or5c1, as ERK is a key player in the signaling events of the target protein. | ||||||