Olfr325 Activators
Chemical activators of Olfr325 include a variety of compounds that induce intracellular signaling pathways leading to its phosphorylation and activation. Forskolin, for instance, works by activating adenylyl cyclase, which consequently raises the levels of intracellular cyclic AMP (cAMP). The increase in cAMP activates protein kinase A (PKA), a kinase that can directly phosphorylate Olfr325, leading to its activation. Similar in its mechanism, Isoproterenol, a beta-adrenergic agonist, also elevates cAMP levels thus stimulating PKA, which then phosphorylates Olfr325. These activations are part of the olfactory signal transduction that allows for the perception of smells.
Other chemical activators work by modulating intracellular calcium levels. Ionomycin serves as a calcium ionophore, raising intracellular calcium concentrations that can trigger the activation of protein kinase C (PKC). PKC has the ability to phosphorylate Olfr325, thereby activating it. Capsaicin targets transient receptor potential vanilloid 1 (TRPV1) channels to cause a similar influx of calcium ions, which can then activate a calcium-dependent signaling pathway culminating in the phosphorylation of Olfr325. Nicotine and ATP, by binding to their respective receptors, also lead to increases in intracellular calcium, which can activate PKC and result in the phosphorylation of Olfr325. Acetylcholine, through muscarinic receptors, and Histamine, through its G-protein-coupled receptors, both initiate signaling cascades that involve increases in intracellular calcium and the activation of PKC, which is known to phosphorylate Olfr325. Furthermore, Dopamine and Glutamate connect to their respective G-protein-coupled and metabotropic glutamate receptors, leading to the activation of the cAMP pathway or the PLC pathway, respectively. Both pathways can result in the activation of kinases like PKA or PKC, leading to Olfr325 activation. Lastly, Oleic Acid may affect membrane receptor function, which can activate G-protein-coupled receptors that signal through pathways involving the phosphorylation of Olfr325.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP can lead to the activation of protein kinase A (PKA), which can phosphorylate and activate Olfr325 as part of olfactory signal transduction. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as a calcium ionophore, elevating intracellular calcium levels, which can activate protein kinase C (PKC). PKC can phosphorylate and activate Olfr325 directly or through downstream signaling cascades involved in olfactory transduction. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that can increase cAMP levels by stimulating adenylyl cyclase. The rise in cAMP can activate PKA, which in turn may phosphorylate and activate Olfr325. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin can activate transient receptor potential vanilloid 1 (TRPV1) channels, leading to an influx of calcium ions. This can stimulate a calcium-dependent signaling pathway, potentially resulting in the phosphorylation and activation of Olfr325. | ||||||
ADP | 58-64-0 | sc-507362 | 5 g | $53.00 | ||
Adenosine triphosphate can bind to P2X purinergic receptors, causing an influx of calcium ions. This can activate downstream signaling that may include PKC, leading to the phosphorylation and activation of Olfr325. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine binds to its G-protein-coupled receptors, which can activate phospholipase C (PLC). PLC increases intracellular calcium and diacylglycerol (DAG), activating PKC, which could phosphorylate and activate Olfr325. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $291.00 $566.00 | ||
Glutamate can activate metabotropic glutamate receptors, which can lead to the activation of PLC. The increase in intracellular calcium and DAG from PLC activation can stimulate PKC, leading to the phosphorylation and activation of Olfr325. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate can inhibit histone deacetylases, leading to a more relaxed chromatin state around certain genes. This does not directly activate Olfr325 but can enhance the cellular context for its functional activation by other signaling molecules. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic Acid can incorporate into cell membranes, possibly affecting membrane receptor function. This can lead to the activation of G-protein-coupled receptors and associated signaling pathways, potentially resulting in the phosphorylation and activation of Olfr325. | ||||||