Olfr325 Inhibitors
Inhibitors that target Olfr325 include a diverse set of chemical entities that disrupt the receptor's capacity for olfactory perception. Certain molecules can directly contest the receptor's natural odorant molecules for binding sites, effectively preventing receptor activation. Alternatively, other agents indirectly influence the receptor by engaging different ion channels, leading to a decreased sensitivity of the sensory neurons where Olfr325 is located, thus dulling the receptor's response to odorous substances. Moreover, specific metal ions function as allosteric modulators that may change the shape of Olfr325, impacting its ability to bind with odorants. These metal ions can attach to distinct parts of the receptor's structure, reducing its overall activity.
Furthermore, various compounds can affect the complex signaling pathways linked to Olfr325's operation. Certain cooling agents interact with temperature-sensitive channels, potentially altering the pathways involved in olfactory detection and diminishing the sense of smell. Some substances can change the internal environment of cells, which may affect the processing and surface availability of receptors like Olfr325, thus impairing their signaling capability. Some chemicals might indirectly curtail Olfr325's function by blocking the electrical signals within the neurons that express the receptor. Other compounds might act as direct antagonists, blocking Olfr325's interaction with its specific odorants and preventing normal olfactory responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Agonist of the transient receptor potential vanilloid 1 (TRPV1) in sensory neurons, capsaicin can lead to desensitization and subsequent decrease in the sensitivity of olfactory receptors like Olfr325 due to the depletion of neurotransmitters. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
As a metal ion that can bind to histidine residues in proteins, copper sulfate may alter the conformation of Olfr325, thus reducing its ability to bind to its odorant ligands. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions can interact with sulfur-containing ligands or histidine residues, potentially causing conformational changes in Olfr325 that may inhibit its normal function. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $38.00 $67.00 | ||
As a compound that affects several TRP channels, may indirectly inhibit Olfr325 by modulating the olfactory signal transduction pathway, resulting in reduced perception of smells. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
By increasing endosomal pH, can affect the trafficking and recycling of G protein-coupled receptors like Olfr325, potentially leading to decreased receptor surface expression and function. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
Can block sodium channels and thus could indirectly inhibit the activity of neurons expressing Olfr325 by preventing action potential propagation. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
Known to activate TRPA1 channels, can cause desensitization of sensory neurons that might express Olfr325, indirectly leading to a decrease in olfactory function. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Interacts with various olfactory receptors and may serve as an antagonist for Olfr325, thereby inhibiting the receptor's ability to detect odors. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
As a TRPV1 agonist, eugenol can lead to the desensitization of sensory neurons, which could indirectly result in the inhibition of Olfr325 activation. | ||||||