Oct-3/4 Inhibitors
Oct-3/4 inhibitors belong to a chemical class of compounds that specifically target and inhibit the activity of the Oct-3/4 protein. Oct-3/4, also known as octamer-binding transcription factor 3/4, is a transcription factor that plays a crucial role in maintaining pluripotency and self-renewal in embryonic stem cells. These inhibitors are designed to bind to Oct-3/4 and interfere with its normal function, thereby modulating the gene expression patterns associated with pluripotency.
By blocking Oct-3/4, these inhibitors have the ability to influence cellular differentiation processes and redirect the fate of stem cells towards more specialized cell types. Oct-3/4 inhibitors are typically small molecules that possess specific structural features enabling them to interact with the Oct-3/4 protein and disrupt its DNA binding or protein-protein interactions. The development of Oct-3/4 inhibitors is an active area of research in the field of stem cell biology, as they provide valuable tools for studying the mechanisms underlying pluripotency and cell fate determination.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat is a histone deacetylase inhibitor that has been reported to downregulate POU5F1 expression in cancer cells. By inhibiting histone deacetylases, SAHA modulates gene expression, including POU5F1, and induces differentiation in certain cell types. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a natural compound found in turmeric, has demonstrated inhibitory effects on POU5FIt acts by suppressing the expression and activity of POU5F1, leading to decreased pluripotency and increased differentiation in stem cells. | ||||||
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $162.00 $241.00 $406.00 $474.00 | 1 | |
Salinomycin is an antibiotic that has been identified as a potent inhibitor of POU5F. It promotes the degradation of POU5F1 protein, thereby inhibiting its transcriptional activity and reducing stem cell-like properties. | ||||||
Thioridazine | 50-52-2 | sc-473180 | 50 mg | $500.00 | ||
Thioridazine has been found to inhibit POU5F1 expression in a broad spectrum of cancer cells. It exerts its inhibitory effects by downregulating POU5F1 at the transcriptional level. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a natural polyphenol compound found in grapes and other plants. It has been reported to inhibit POU5F1 expression in various cancer cell lines. The precise mechanism of action is not fully understood, but it is believed to involve modulation of multiple signaling pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin has been found to inhibit POU5F1 expression. It acts by inhibiting the mTOR pathway, which plays a role in regulating POU5F1 expression and pluripotency. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a derivative of vitamin A, is a well-known inducer of stem cell differentiation. It has been shown to downregulate POU5F1 expression and promote lineage-specific differentiation in various cell types. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a catechin found in green tea and has been shown to inhibit POU5F1 expression in cancer cells. It affects multiple signaling pathways involved in stemness and differentiation. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $38.00 | 13 | |
Chrysin is a natural flavonoid compound found in various plants and honey. It has been reported to inhibit POU5F1 expression in cancer cells, thereby influencing their pluripotency and self-renewal capabilities. | ||||||