Nup160 Activators
Nup160 Activators encompass a diverse range of chemicals that can indirectly influence or prompt the activity of the Nup160 protein, an integral component of the nuclear pore complex (NPC). Their mode of action predominantly revolves around targeting the processes related to nuclear transport or the structural integrity of the nuclear envelope. For instance, agents like Leptomycin B target exportin-1, thereby inhibiting nuclear export. Such an action can lead to an upregulation or increased activity of Nup160 as the cell seeks to maintain nucleocytoplasmic balance. Similarly, Importazole's inhibition of importin-β affects the nucleocytoplasmic transport equilibrium, placing a demand on Nup160 to adjust and maintain effective transport.
Several compounds in this category interface with cellular processes that can have downstream implications on nuclear transport dynamics, thus indirectly affecting Nup160. Paclitaxel and Nocodazole, which impact microtubule dynamics, can indirectly influence nuclear positioning and its associated transport processes, thereby placing demands on Nup160. Other agents like A23187 elevate intracellular calcium levels, which can ripple through various cellular processes, including nuclear transport, necessitating a heightened activity of Nup160. Similarly, Digitonin, by permeabilizing membranes, may cause disruptions that require compensatory actions involving Nup160.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
By inhibiting nuclear export via targeting exportin-1, it may cause an upregulation or activation of Nup160 as a compensatory response to maintain nucleocytoplasmic balance. | ||||||
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $57.00 $77.00 | 2 | |
By inhibiting importin α/β-dependent nuclear import, Ivermectin can potentially cause Nup160 to enhance its role in alternative transport mechanisms. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
The stabilization of microtubules can impact nuclear positioning and indirectly place demand on Nup160 for maintaining nuclear transport. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Its effect on microtubules might indirectly necessitate increased activity or expression of Nup160 to cope with nuclear transport alterations. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Elevated intracellular calcium levels can affect various cellular processes. This alteration might stress nucleocytoplasmic transport, potentially requiring Nup160 activation. | ||||||
Digitonin | 11024-24-1 | sc-280675A sc-280675 sc-280675B sc-280675C sc-280675D sc-280675E | 100 mg 250 mg 1 g 2.5 g 5 g 10 g | $84.00 $180.00 $385.00 $935.00 $1679.00 $2929.00 | 10 | |
Membrane permeabilization may disrupt nuclear integrity, leading to possible compensatory responses, including heightened activity of Nup160. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
Affecting protein neddylation might have downstream implications for NPC function, possibly necessitating enhanced Nup160 activity. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Impact on DNA synthesis could lead to nuclear transport imbalances, indirectly prompting increased function or expression of Nup160. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Protein synthesis inhibition might place a demand on nuclear transport processes, potentially requiring increased activity of Nup160. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Interruption in DNA replication and transcription could indirectly affect NPC dynamics, potentially involving an activation response from Nup160. | ||||||