NUDT18 Activators
NUDT18, also known as CoA pyrophosphatase, is a protein encoded by the NUDT18 gene in humans. This enzyme belongs to the Nudix (nucleoside diphosphate linked to some other moiety X) hydrolase family, which is known for its role in the hydrolysis of various nucleoside diphosphate derivatives.
NUDT18 specifically functions to hydrolyze Coenzyme A (CoA) and dephospho-CoA (dpCoA) to 3',5'-ADP and 4'-phosphopantetheine, respectively. CoA and its derivatives are central to numerous metabolic processes, including the synthesis and oxidation of fatty acids, as well as the metabolism of many other acids and alcohols through acetylation and acylation reactions. By regulating the levels of CoA and dpCoA, NUDT18 plays a critical role in maintaining the balance of CoA-related metabolic pathways.
The activity of NUDT18 is important for cellular health because CoA is essential for energy production and lipid metabolism. CoA must be tightly regulated within cells, as imbalances can lead to metabolic dysfunctions. For example, excess CoA can inhibit mitochondrial fatty acid β-oxidation, leading to the accumulation of fatty acids within the cell.Alterations in the function or expression of NUDT18 can have significant physiological implications. While research on NUDT18 is not as extensive as for some other proteins, understanding its role in CoA metabolism is crucial. It may have implications for conditions characterized by metabolic disturbances, such as diabetes, obesity, and certain types of liver diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
Increases cellular glutathione levels, enhancing antioxidant capacity and potentially influencing NUDT18's role in oxidative stress response. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $82.00 $2091.00 | 8 | |
A tripeptide that acts as an antioxidant, potentially affecting NUDT18 activity by modulating oxidative stress. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenol that activates SIRT1, potentially affecting NUDT18 through indirect regulation of oxidative stress and DNA repair pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
An isothiocyanate that activates Nrf2, potentially influencing NUDT18 by enhancing cellular antioxidant responses. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A compound from turmeric with antioxidant properties, possibly impacting NUDT18 activity by modulating oxidative stress. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
An antioxidant that could indirectly influence NUDT18 by affecting cellular redox states. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
A molecule involved in the electron transport chain, potentially affecting NUDT18 by influencing redox balance. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
A well-known antioxidant, possibly impacting NUDT18 activity by modulating oxidative stress. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A catechin from green tea, known for its antioxidant properties, which could indirectly affect NUDT18. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid with antioxidant effects, potentially influencing NUDT18's function in oxidative stress response. | ||||||