NSUN5C Inhibitors
NSUN5C inhibitors belong to a class of chemical compounds that specifically target the NSUN5C enzyme. NSUN5C, a member of the NOL1/NOP2/SUN domain (NSUN) family of methyltransferases, plays a crucial role in the methylation of various RNA molecules, particularly transfer RNA (tRNA). These inhibitors are designed to bind to the active site of NSUN5C, thereby preventing its enzymatic activity and inhibiting its ability to methylate RNA. By targeting NSUN5C, these inhibitors have the potential to modulate the methylation status of tRNA and other RNA species, which may have downstream effects on cellular processes that rely on properly methylated RNA, such as protein translation and gene expression regulation.
The development of NSUN5C inhibitors is a promising area of research in the field of chemical biology, as they have the potential to provide valuable insights into the role of RNA methylation in cellular function. By selectively inhibiting NSUN5C, researchers can study the specific effects of altered RNA methylation patterns on cellular processes, which could lead to a better understanding of the underlying mechanisms. Furthermore, NSUN5C inhibitors may also serve as valuable tools for studying the potential implications of targeting RNA methylation pathways in the context of cellular function and dysfunction.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A cytidine analog incorporated into RNA and DNA and inhibits DNA methyltransferases, which could lead to hypomethylation and indirectly reduce NSUN5C activity, as NSUN5C is involved in RNA methylation. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A non-nucleoside DNA methyltransferase inhibitor that prevents DNA methylation. By inhibiting DNA methylation, RG108 may indirectly decrease NSUN5C function by affecting the methylation patterns within the RNA substrates NSUN5C might act upon. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Another DNA methyltransferase inhibitor that incorporates into DNA and can disrupt methylation patterns. This could alter the RNA methylation landscape, potentially reducing the methylation activity of NSUN5C. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
A cytidine deaminase inhibitor that is also incorporated into DNA and exerts a demethylating effect. By changing the methylation status of DNA, Zebularine could indirectly affect NSUN5C's substrate availability or methylation activity. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
A vasodilator that also inhibits DNA methylation. Its action may lead to a general reduction in methylation processes within the cell, potentially lowering NSUN5C activity in RNA methylation. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
that binds to DNA and inhibits RNA synthesis. This could decrease the amount of RNA available for NSUN5C to methylate, thus indirectly inhibiting its activity. | ||||||
Novobiocin | 303-81-1 | sc-362034 sc-362034A | 5 mg 25 mg | $128.00 $380.00 | ||
A DNA gyrase inhibitor that could indirectly affect RNA synthesis and processing, possibly reducing the substrate availability for NSUN5C's methylation activity. | ||||||
Sinefungin | 58944-73-3 | sc-203263 sc-203263B sc-203263C sc-203263A | 1 mg 100 mg 1 g 10 mg | $271.00 $5202.00 $40368.00 $704.00 | 4 | |
A natural nucleoside that inhibits methyltransferases, which could lead to reduced RNA methylation activity of NSUN5C indirectly by competing with the methylation substrate, S-Adenosylmethionine. | ||||||
Lomeguatrib | 192441-08-0 | sc-362764 sc-362764A | 10 mg 50 mg | $205.00 $865.00 | ||
A potent inhibitor of the MGMT DNA repair enzyme that could also affect the methylation status of RNA indirectly, thereby potentially decreasing the activity of NSUN5C. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
A thiodioxopiperazine that inhibits histone methyltransferases. By altering histone methylation, it could indirectly affect the RNA methylation processes that NSUN5C is involved in. | ||||||